Tetracycline antibiotics arequite an extensive group of drugs. Medicines have a similar chemical structure. It should be noted that these funds are on one of the leading places among the drugs of a wide range of activity.
Tetracycline antibiotics. Description
Препараты в этой группе оказывают угнетающее influence on reproduction and development of gram-negative, gram-positive bacteria, bacilli (acid-resistant), large viruses, other microbes. The category includes drugs such as chloro-tetracycline hydrochloride, oxytetracycline hydrochloride, tetracycline, and others. The study of medicines was started in 1948. Due to certain difficulties in the synthetic preparation of drugs, they are created today with the help of biosynthesis. All tetracycline antibiotics differ in their amphoteric character. Their main qualities are due to dimethylamino-group. Their acidic properties of the drug are due to phenolic hydroxyl in the D-ring.
All tetracycline compounds have spectrasimilar to each other. In molecules, phenolic hydroxyl causes a color change during interactions with ferric chloride (3). Tetracycline antibiotics are decomposed by alkali before the formation of isotetracyclines. In turn, this is accompanied by an increase in staining. General reactions are common to all tetracycline compounds. It is possible to distinguish drugs from each other due to different staining under the influence of sulfuric acid (concentrated). When this occurs, the formation of compounds colored for each tetracycline in a particular color. So, for example, for one appears a purple-red hue, for the other - purple. One of the characteristic features is the ability of drugs to fluoresce under the influence of UV light. This is often used as proof of their authenticity.
Pharmacological properties of tetracycline
This drug is quite widespectrum of activity. Its bacteriostatic effect occurs due to inhibition of the protein synthesis of pathogen bacteria. The activity of the drug is manifested relative to gram-positive aerobic microbes, including penicillinase-producing strains. The drug also affects gram-negative bacteria. Drug resistance to small viruses, most fungi and a number of other strains.
Some rules for taking antibiotics. Adverse reactions
Рекомендуется применение препаратов в дозе по 0,3 grams in the first two days, 0.2 grams five times in the following days. For gonorrhea (subacute and acute uncomplicated), a course of 5 g is prescribed for a course, 10 for other forms. It is recommended to take the medicine before or during meals. Against the background of the use of stomach upset, vomiting, nausea.
