Drug with the trade name"De-Nol" is recognized as an effective gastroprotector. Also, doctors prescribe this tool for various pathologies of the stomach. Tablets "De-Nol" have antiseptic, astringent, anti-ulcer and anti-inflammatory action.
Indications
Pain in the epigastric region,violation of the digestive process, belching, heartburn - this is just a short list of warning signs with which a person refers to a gastroenterologist or therapist. After all the necessary diagnostic measures have been taken, the doctor draws up the most effective treatment regimen, which often includes the use of De-Nol tablets.
The drug is not an antibiotic.Nevertheless, based on the information specified in the instructions for use, "De-Nol" helps to rid the body of the pyloric helicobacter - the causative agent of functional dyspepsia and gastritis. The active ingredient of the drug penetrates directly to the site of pathogenic microorganisms, and then destroys them in a short time. The drug also improves the course of many ailments affecting the gastrointestinal tract.
Indications for "De-Nolu":
- Gastritis, gastroduodenitis (both acute and chronic).
- The defeat of the duodenum, perforation of the stomach walls of any degree of severity, including the peptic form.
- IBS.
- Functional dyspepsia.
- The defeat of the mucous membrane of the digestive organ, which is a consequence of hormonal and non-steroidal anti-inflammatory drugs.
- GERD - a pathology of a chronic nature, which is accompanied by the penetration of the contents of the stomach back into the esophagus.
- Iron deficiency anemia, which persists for a long time. In this case, the reason for its appearance is not established.
Also the indication for "De-Nolu" isprevention of relapse after surgery in the stomach, carried out with the aim of treating an ulcer or removing a malignant neoplasm. In addition, the drug is recommended to be taken in people whose immediate family has suffered from digestive organ cancer.
Form of issue, composition
The drug "De-Nol" is implemented incardboard boxes. Each of them contains 7 or 14 blisters of 8 tablets. The manufacturer specifies that the package may contain a faint ammonia smell.
Tablets have a round and biconvex shape.Each is covered with a shell. The color of the tablets is light cream. The manufacturer has thought over the anti-counterfeiting system. On each tablet you can see the graphic embossing of gbr 152 on both sides. In addition, they are patterned in the form of a square with breaks on the lines of the sides and slightly smoothed corners.
The instructions for use "De-Nol" indicated thatthe active ingredient of the drug is tricalium decitrate bismuth. In one tablet it is contained in the amount of 304 mg. In addition, the composition is represented by the following auxiliary components: corn starch, magnesium stearate, hypromellose, potassium polyacrylate, povidone K30.
Active ingredient in contact with waterforms a colloid, which, in turn, is able to penetrate into the mucous layer, enveloping the walls of the stomach. There it breaks down into compounds, forming a protective film.
Tri-potassium decitrate bismuth has the following positive effects:
- Increases the degree of resistance of the mucous membrane of the digestive system to adverse factors.
- Destroys pathogenic microorganisms. The active substance destroys their shell, prevents the vital activity and the fixation of bacteria to the wall of the organ.
- It contributes to the speedy recovery of the mucous membrane.
- Reduces the activity of gastric juice.
The advantages of the drug include the fact that its action does not violate the process of digestion. Even with long-term treatment, pathogens do not develop resistance to the agent.
Instructions for use
"De-Nol" is appointed only by the attending physician, who takes into account the results of diagnosis. At the same time in the scheme of therapy should be absent drugs, which include bismuth.
The important thing is how to take “de-nol” - untilmeal or after meal. In order for the active substance to benefit, it must penetrate the walls of the stomach. If even a small amount of food is in the body at this time, tricalium decitrate of bismuth will mix with it and leave the body naturally. As a result, the body will not have even a minimal positive effect. That is why the drug must be taken strictly on an empty stomach. Within the next 30 minutes it is forbidden to drink and eat any food.
Based on the instructions for use, "De-Nol" is recommended to take according to the following scheme:
- Children under 12 and adults. The daily dose of the active substance is 480 mg. During the day, you need to drink 4 tablets. They can be divided into 2 or 4 doses.
- Persons 8-12 years old. Daily dosage is 240 mg. It is necessary to take 1 tablet twice a day.
- Children 4-8 years. The pediatrician calculates the daily dosage individually. Per 1 kg of body weight of the child should account for 8 mg of active substance.
Tablets must be swallowed whole.It is unacceptable to chew, crush and chop them in any other way. While taking the drug, it is necessary to ensure that a sufficient amount of fluid enters the stomach. It is recommended to drink the tablets with clean non-carbonated water. Along with the medicine, it is prohibited to consume milk, nectars, vegetable and fruit juices.
The duration of treatment "De-Nol" is from 3weeks to 2 months. This period is explained by the fact that even after getting rid of pathogenic microorganisms, a high activity of inflammatory processes remains in the stomach. The exact duration of treatment is indicated by the doctor when prescribing De-Nol. The course depends on the existing disease, its severity. Also taken into account are individual patient health features.
Contraindications
"De-Nol" is not recommended for people suffering from the following ailments:
- disorders of the kidneys;
- severe allergic reactions;
- individual intolerance to the components of the drug.
Препарат запрещено принимать женщинам при pregnancy and lactation. This is due to the likely negative effects on the fetus and the penetration of the active substance into breast milk. Bismuth is a heavy metal, therefore, if there is a vital need for its admission, it is necessary to stop breastfeeding during the period of treatment.
In addition, a contraindication to "De-Nola"is the age of children under 4 years old. He is also not appointed if the patient has recently taken drugs containing bismuth to treat other pathologies.
Side effects
Most often in patients receiving the funds, the following conditions appear in patients:
- nausea;
- flatulence;
- increased urge to commit an act of defecation or, conversely, constipation;
- a violation of appetite;
- the presence in the mouth of metallic taste;
- fecal masses acquire a different shade (from dark brown to black).
The presence of the above side effects“De-Nola” is not a reason for going to a doctor. Their occurrence is due to the adaptation period. These states pass without any intervention, their presence does not mean that the treatment should be interrupted.
Less commonly, patients have allergic reactions.As a rule, they appear in the form of itching and rashes on the skin. The decision as to whether it is advisable to continue treatment should be made by a physician. There have been isolated cases of anaphylactic shock as a side effect of De-Nol.
The duration of drug treatment should beno more than 2 months. This period may increase the doctor, but only if there is a vital need. This is due to the fact that with long-term treatment significantly increases the risk of the following diseases:
- nephropathy;
- arthralgia;
- gingivitis;
- pseudomembranous colitis;
- encephalopathy.
The starting factor for the occurrence of these pathologies is the accumulation of bismuth in the central nervous system.
With strict adherence to the prescribed treatment regimenthe risk of complications is minimal. They disappear on their own after taking the medication. As a rule, serious complications are extremely rare. In most cases, they are the result of an unjustified increase in dosage or duration of treatment. When they appear, you need to consult a doctor.
Overdose
Judging by the reviews, "De-Nol" is well tolerated.by patients. Danger to health is the drug intake in a dosage 10 times higher than the standard. In such cases, renal failure develops.
Deterioration of well-being can occur on the backgroundlong-term treatment, in which a large amount of bismuth accumulated in the tissues of the central nervous system. In this situation, symptomatic therapy is indicated. This completes the treatment course "De-Nol".
In case of acute poisoning, you must call an ambulance.help. Before the arrival of the doctors, it is recommended to wash the affected stomach, give it sorbents and saline laxatives. In severe cases, the patient is hospitalized. In the hospital, the patient is prescribed hemodialysis and taking medications that restore the normal functioning of the kidneys.
Compatibility with other drugs and alcohol
It happens that the patient simultaneously with "De-Nol" takes other drugs designed to get rid of the pathologies of the gastrointestinal tract.
In this case, their compatibility must be considered:
- Proton pump inhibitors.These include: “Omez”, “Omeprazol”, “Nolpaza”, “Pantan”, “Ulsepan”, “Pariet”, “Rabiyet”, “Ontime”, “Epicurus”, “Lantsid”, “Gelikol”, etc. Between taking any of these funds and the use of De-Nol should take at least half an hour.
- Antacids.The most common drugs: "Gastratsid", "Fosfalyugel", "Maalox", "Renny", "Vikalin." Products containing bismuth and antacids are incompatible. Between their techniques should take at least half an hour.
In addition, De Nol andalcohol. In any form of treatment it is not recommended to use alcoholic beverages, especially for people with certain stomach diseases. Alcohol irritates the walls of the body, preventing the penetration of the active substance into them. Also, the drug is often prescribed simultaneously with antibiotics. If at the same time to take and alcohol, and "De-Nol", the toxic effects on the liver will increase significantly.
Analogues
Currently on the pharmaceutical market there are several products whose active ingredient is bismuth tri-potassium dicitrate.
The most well-known analogues of "De-Nola" are the following drugs:
- «Улькавис». Содержит 303 мг активного вещества.It is an anti-ulcer and anti-inflammatory agent, which inhibits the vital activity of the Helicobacter pylori bacteria. The drug must be taken 4 times a day for half an hour before the meal. Dosage for children - 1 tablet twice a day. The following side effects may occur while taking the drug: nausea, vomiting, frequent urge to defecate, and allergic reactions. Ulcavis is most often recommended by doctors as an analogue of De-Nol.
- Novobysmol.An antiseptic and anti-ulcer agent, the dosage regimen of which is also identical to the De-Nol dosing regimen. The manufacturer notes that during treatment with Novobismol, not only fecal masses, but also the tongue can darken. The duration of treatment should also not exceed 8 weeks.
- Escape.Antiulcer and gastroprotective agent with bactericidal activity against Helicobacter pylori. It has the same indications and limitations as De-Nol. The regimen is also identical to the latter.
The drug Venter has a similar effect.Its active ingredient is sukrafalt. Unlike products containing bismuth, this drug has the ability to bind fatty acids much better. However, the active substance has no effect on the bacterium Helicobacter pylori.
Reviews
Most patients feel betterjust a few days after starting the drug. Judging by the reviews, "De-Nol" in a short time eliminates the unpleasant symptoms associated with the development of gastritis, peptic ulcer and other pathologies of the gastrointestinal tract.
Doctors prescribe this drug to their patients.most often. This is due to its high degree of efficiency. In most cases, when re-examining specialists identify significant improvements in patients.
Finally
Currently organ diseasesThe digestive system is diagnosed very often. To combat them, doctors in most cases prescribe "De-Nol". This is a modern drug, the active substance of which penetrates into the walls of the stomach and forms a protective layer that prevents the influence of negative factors on the body. In addition, it contributes to the speedy recovery of its mucous membrane.
According to the instructions for use, "De-Nol"must be taken 4 times a day (or twice a day, but 2 tablets at once). The main contraindications are: pregnancy, lactation and children under 4 years. Based on the information in the instructions for use, the drug has a number of side effects, the risk of which is minimal with strict adherence to the regimen and dosing regimen.
