Nicotinic acid is able to exertthe human body has a diverse effect. This allows to use it for the therapy of many diseases of the circulatory system, stomach and intestines, as well as diseases that develop against the background of atherosclerosis and pellagra.
Nicotinic acid actively participates in allprocesses of metabolism - in protein, and in fat, and in carbohydrate. This is due to the fact that it is part of those enzymes that accelerate the oxidative and reductive reactions.
Particularly active drug affects the exchangefats. It favors the reduction of cholesterol in the blood (especially the "bad"), which contributes to the formation of plaques in the blood vessels. The amount of a useful organic compound that actively participates in the metabolic processes is also capable of increasing nicotinic acid. Indications for the use of this drug for these reasons are the following: most ailments developing against the background of atherosclerosis, for example, obliterating endarteritis (blockage of the arteries of the periphery), ischemic disease of the brain and heart.
Acceleration of blood flow
Among other things, nicotinic acidacts in an expanding manner on capillaries (small vessels). This contributes to the influx of blood and the improvement of the supply of various organs. Thus, it can accelerate the process of tissue regeneration, healing of ulcers and wounds of nicotinic acid. Indications for the use of this drug in this case: many ailments of the intestine and stomach during remission (between exacerbations).
Administration of the medicinal product
Primarily, the drug helpswhen treating pellagra. This disease develops due to a deficiency of nicotinic acid. In this case, there are violations in the metabolism, which lead to the defeat of the skin, as a result of which there is itching, swelling, redness. Also, with pellagra, the work of the intestine, the stomach (including language suffers), the brain (the result is dementia) is disrupted. In the case of a slight development of the disease and the absence of severe consequences for the central nervous system, nicotinic acid therapy is quite effective.
Treatment of ailments of the stomach and intestines
For the treatment of any other pathologies, nicotinic acid is used? Indications for the use of the drug can be the following - a variety of ailments of the intestines and stomach. Namely:
- Peptic ulcer of the duodenum and stomach.
- Colitis.
- Enteritis.
- Pancreatitis in chronic form.
In all these cases, the use ofnicotinic acid is permissible only during remission (not at the time of exacerbation). Especially it is necessary to use this medicine carefully in the treatment of peptic ulcer, as it can accelerate the secretion of gastric juice during an exacerbation. As a consequence, vasodilatation is possible, which leads to complications of ailments and bleeding.
Malabsorption syndrome
There are also diseases of the intestines and stomach,which significantly reduce the rate of absorption of the small intestine components of food and nicotinic acid. This pathology is called "malabsorption syndrome". He accompanies many diseases that develop in the gastrointestinal tract. With such a syndrome, the introduction of nicotinic acid into the body is done intravenously or intramuscularly.
Lack of acid
It happens that the nicotinic acid deficiencyobserved in the body in case of malnutrition. A regular menu based on one type of product, the absence of animal proteins, fruits, and vegetables in the diet makes it impossible to saturate the systems and organs of the body with a sufficient amount of it. In this case, the drug is administered orally or by injection.
There is also a shortage of nicotinic acid.due to severe infectious diseases, accompanied by a significant increase in body temperature due to a prolonged inflammatory process. In this case, the drug is prescribed only outside the period of exacerbation. In the case of chronic cirrhosis or hepatitis, nicotinic acid is not used.
Other pathologies
What other cases use nicotinic acid? Indications for use may be as follows:
- Atherosclerosis and ailments associated with it - endarteritis obliterans, CHD. The use of acid accelerates the exchange of cholesterol, dilates blood vessels, improves blood supply to tissues and organs.
- Trophic ulcers and wounds. Nicotinic acid promotes rapid tissue regeneration and healing.
- Restoring the normal functioning of many organs. The drug in this case acts as a vitamin.
Nicotinic acid: side effects
Take the drug is not acceptablemore than 6 grams per day. For a better perception of the body nicotinic acid should be used only after meals and drink warm beverages. In the initial stage of therapy with this drug, it is necessary to control the blood glucose level. Also, kidney function should be monitored to detect the side effects of the acid.
Sometimes the drug is ill perceived by the sick,sometimes there is redness of the skin and hot flashes. The reason for this is the increased synthesis of prostaglandins, disorders in the gastrointestinal tract, hyperuricemia and a decrease in the response to glucose. For this reason, not every organism is able to perceive effective, but large doses of nicotinic acid (from 3 to 5 grams per day).
Toxic effects of the drug
This drug is a prolonged action.occasionally leads to serious toxic effects on the liver. Therefore, long-term use of nicotinic acid implies control of the work of this body. Such an effect of the drug on the liver is due to its methylation. Before the hepatotoxic effect of nicotinic acid begins to manifest, the level of lipids is dramatically reduced in the blood.
Hypovitaminosis
Prolonged use of nicotinic acid inlarge quantities leads to the displacement of ascorbic acid from the body. This phenomenon is called hypovitaminosis. In order to prevent it, it is advisable to add ascorbic acid supplements.
Other deviations
When using nicotinic acid, the following deviations can also be observed:
- Increasing the acidity level of the juice in the stomach (aggravation of the ulcer).
- Hyperglycemia.
- An increase in the frequency of atrial arrhythmias in patients with ischemic disease (rarely, but possible).
- The appearance of brown spots with velvety cover on the skin (acanthosis).
- Puffiness of a retina of eyes (quite rare side effect).
All the listed symptoms are rather unstable and disappear after stopping the use of nicotinic acid.
Drug price
Сколько же стоит никотиновая кислота?The price in Russian pharmacies ranges from 10.90 rubles. for 50 tablets in a dosage of 0.05 grams. The maximum cost is approximately 81 rubles per 10 ampoules of the drug at a dosage of 10 mg / ml.
