The discovery of the antibacterial action of moldThe fungi of which penicillin was made became a real revolution in medicine. But over time, the pathogenic microflora has adapted to the action of this drug. This forced scientists to develop synthetic analogues of penicillin, one of which was Flemoxin Soluteb. Instructions, a description of the drug will help avoid its negative effects on the body and side effects.
Active ingredient of the drug
The composition of one tablet "Flemoksina" includesacid-resistant amoxicillin in the form of amoxicillin trihydrate 125, 250, 500 and 1000 milligrams. This substance has a strong bactericidal action. Also used drugs with amoxicillin against gram-positive and gram-negative bacteria. It is sometimes used to combat pathogens of intestinal infections. But in the latter case, it is less effective.
Dosage form, composition
What is the "Flemoksin Solutab"(500 mg)? Instructions for use describes the drug in various dosages (125 and 250, 1000 and 500 mg) as oval tablets having a light yellow color. On each tablet, on the one hand, there is a company logo and a digital designation, and on the other hand, risk.
In the manufacture of the drug, such excipients were used as monocrystalline cellulose, vanillin, dispersible cellulose, magnesium stearate, crospovidone, saccharin, flavors.
The drug is intended for systemic use and is a broad-spectrum medicine.
Pharmacological effects on the body
How does Flemoxin Solutab affect the organism?(Flemoxin Solutab)? The instruction states that after taking the active ingredient of the drug - amoxicillin - almost all are absorbed as soon as possible (almost 93 percent). Moreover, the absorption of the drug has nothing to do with food intake.
The maximum amount of drug in the blood plasmadetected one to two hours after ingestion. After entering the digestive tract of the drug "Flemoxin Soluteb 500 mg" (this confirms the instructions for use), the maximum concentration of amoxicillin by researchers is noted after 2 hours. This maximum is 5 µg / ml. If, for any reason, the dose of the medicinal product decreases or increases, then its concentration, respectively, decreases or increases.
Twenty percent of the substance is associated withplasma proteins. The therapeutic effect is achieved almost always, as the drug penetrates perfectly into the intraocular fluid, bones, mucous membranes, sputum. Amoxicillin bile gets into two, or even four times more than in the plasma. In the umbilical cord and amniotic substance found twenty-five - thirty percent of flemoxin from its concentration in the blood of a pregnant woman.
Poor penetration of the active substance through the blood-brain barrier was noted: its amount in the cerebrospinal fluid when consumed does not exceed twenty percent.
The drug is excreted by the kidneys.Eighty percent of the active substance is processed by tubular excretion, the remaining twenty are filtered into glomeruli. Healthy kidneys produce amoxicillin for an hour and a half. In children up to six months, the half-life is from three to four hours. Disorders in the liver do not affect the half-life of the drug.
Pharmacodynamics
Flemoksin Solutab (tab. 500 mg, 20 pcs., as well as other dosages of the drug) is an acid-resistant bactericidal antibacterial agent with a broad spectrum of action. They relate it to the group of semi-synthetic penicillins.
Detrimental effect on many gram-negativeand gram-positive microorganisms, such as most varieties of streptococci, clostridia, staphylococci, Helicobacter pylori, Escherichia coli, Proteus, Salmonella, Vibrio.
In what cases the drug is prescribed
- during infectious processes in the respiratory tract;
- with infectious ailments of the urinary organs;
- for the treatment of gastrointestinal infections;
- with skin infections and infectious processes in soft tissues.
Who is contraindicated use of the drug
"Flemoksin Solyutab" (table.500mg n20), the instruction confirms this, it has not only advantages, it has its own contraindications. This is true for other dosages of the drug. The drug is not prescribed or prescribed with great care in such cases:
- if the patient had an allergic reaction to him or other antibiotics of this series;
- a patient with lymphocytic leukemia or infectious mononucleosis;
- children under six years prescribed with caution in the form of a suspension;
- with renal insufficiency;
- in diseases of the gastrointestinal tract, especially arising from the use of antibiotics;
- pregnant women or during breastfeeding is prescribed, if the need to use the tool outweighs the possible risks.
Drug use by adults
Infectious diseases of the stomach, intestines and biliaryways, as well as infectious diseases gynecological diseases are treated with three times a dose in a dosage of from one and a half to two grams or four times a day - in a gram-one and a half at a time.
Adult people with leptospirosis are treated with a fourfold intake of "Flemoxin Soluteb" of 0.5-0.7 grams. Treatment should last from six to twelve days.
Carrying salmonella requires three to one and a half to two grams for two to four weeks.
To avoid endocarditis with smallsurgery, prescribed three to four grams of the drug for an hour before surgery. If there is a need to re-use the drug, then it is prescribed after eight to nine hours at the same dosage.
In case of a malfunction of the kidneys, the interval betweenreceptions should be up to 12 hours. For more serious violations reduce the dose. If the patient has anuria - the maximum dose should not exceed two grams.
"Flemoxine Solutab" for children - dosage
Newborn and premature babies reduce the doseor increase the interval between doses. For the prevention of endocarditis in small surgical operations prescribed an hour before the procedure, one and a half to two grams. If necessary, reappoint eight to nine hours after surgery.
What side effects may be accompanied by the use of the drug
Whatever medicine is perfect, from whatever natural ingredients it is created, there are risks of side effects that can affect the patient's condition.
- Allergic reactions can give anydosage of the drug, including "Flemoksin Solutab" 500 mg 20, the price, the instruction of which is almost the same in all used dosage forms. There may also be reddening of the skin, rash in the form of erythema, angioedema.
- Occasionally marked serum sickness and anaphylactic shock, fever, eosinophilia, arthralgia.
- On the part of the digestive organs, nausea, dysbacteriosis, diarrhea, vomiting, changes in taste, and pseudomembranous enterocolitis are possible. ALT and AST may increase.
- Changes in the nervous system: there may be disturbed sleep, anxiety, depressive phenomena, pain and headache, episyndrome, impaired consciousness, ataxia.
- Laboratory indicators change: the number of leukocytes, erythrocytes decreases, hemoglobin decreases, neutropenia is noted.
- Possible respiratory failure, increased heart rate, nephritis, vaginal candidiasis, even more infection (in patients with chronic processes and reduced immunity).
- An overdose of the drug appears asdiarrhea, vomiting and nausea, due to which water and electrolyte imbalance may be observed. Assign gastric lavage, saline laxatives, activated carbon, sometimes - hemodialysis.
Flemoksin Solutab: reviews, analogues, application
This drug is rated by patients as veryeffective and relatively safe. It is bioavailable, so the effect of it appears very quickly. After the start of treatment, the condition of adults and children improves during the first days. Depending on the dosage and destination, "Flemoxin Solutab" is very quickly absorbed into the blood. Its effect lasts for eight hours. The concentration of the substance is observed 15 minutes after use.
According to experts, for children this antibiotic is one of the safest. It is used from early childhood as prescribed by a doctor.
This drug has many synonyms, that ismedicines that are made on the basis of amoxicillin. But there are also some medications with another active ingredient, but used for the same health problems as Flemoxine Soluteb. Such drugs are called analogues of the above. The active ingredients in them are also antibiotics, semisynthetic penicillins. They are used for sepsis, abscesses, infections of upper respiratory tract and respiratory tract, urinary tract, skin, gastrointestinal tract, soft tissue and so on.
These drug analogues include:
- "Azlocillin" - the active substance azlocillin.
- Ampic - works with ampicillin.
- "Geopen" - the main substance of carbenicillin.
- "Isipen" - the active substance piperacillin.
- "Penglob" - affects the body with bakampicillin.
- "Flucloxacillin" - the active substance has the same name.
Analogues of the drug, especially antibiotic,need to be discussed with your doctor. This is very important, since the dosage, nature of treatment and duration are determined only by a specialist. He also knows better what active ingredient is suitable in a particular case.
Features of the drug, the price
If the drug treatment is carried out by courses, the function of the kidneys, liver, hematopoiesis should be monitored.
If the patient is sensitive to the penicillin group, allergic cross-reactions can occur.
If mild diarrhea occurs during treatment,It is necessary to avoid drugs that reduce intestinal motility. If you experience severe diarrhea, you should seek advice from a hospital. After the disappearance of the clinical manifestations, it is recommended to take Flemoxin Solutab for another three to four days.
The drug can reduce the contraceptive effect.from oral contraceptives, so during its reception should take care of additional contraception. It also does not work well with aminoglycosides, indirect anticoagulants, methotrexate, digoxin, alopurinol, diuretics, oxyphenbutazone.
Before applying it is important to familiarize yourself with the peculiarities of the use of the drug "Flemoxine Solutab". Instructions for use, reviews will help to avoid undesirable consequences.
Цены на лекарственное средство в разных городах range from 176 rubles (in Nizhny Novgorod) and up to 228 rubles (in Novosibirsk). In the capital, "Flemoksin Solutab" can be purchased at a price of 191 rubles. In St. Petersburg, it costs an average of 184 rubles.
Do not forget that the instructions for use of the drug "Flemoksin Solutab" mainly compiled for the doctor. And only he can prescribe or cancel the drug. Avoid self-medication!
