Tranexan has a local and systemichemostatic effect in conditions accompanied by increased amounts of fibrinolysin (platelet pathology, menorrhagia). The medication is able to suppress the formation of kinins and other active peptides involved in inflammatory and allergic processes. Thus, Tranexan has antitumor, anti-infective, anti-allergic and anti-inflammatory properties.
Excretion is performed by the kidneys.If their function is disrupted, cumulation (accumulation) of tranexamic acid can be noted. The drug penetrates through the blood-brain and placental barrier, evenly distributed in the tissues. Concentration lasts for seventeen hours. The maximum level of the drug in the plasma is noted after three hours after oral administration.
Tranexan. Description of indications
As a haemostatic agent withbleeding or the likelihood of their development as a result of increased fibrinolysin during operations, during the postoperative period, with manual separation of the afterbirth, postpartum bleeding, chorion detachment, malignant tumors of the prostate and pancreas, liver diseases, leukemia, bleeding during gestation.
With bleeding or the likelihood of their development onbackground of local strengthening of fibrinolysin in uterine, nasal bleeding, and also in the digestive tract. These states include hematuria, tooth extraction in patients with hemorrhagic diathesis.
The drug "Tranexan" instruction allowsUse as an antiallergic agent for allergic dermatitis, hives, eczema, skin rashes, provoked by toxins and drugs.
The medication is prescribed for stomatitis, laryngitis, pharyngitis, tonsillitis as an anti-inflammatory therapy.
The drug is also used for angioedema edema of a hereditary nature.
Tranexan. Instructions for use
When strengthening fibrinolysin local characterrecommended from 1 to 1.5 g three or four doses per day. With repeated bleeding from the nose - during the week for three doses of 1 g. After extraction (extraction) of the tooth for six to eight days for three or four doses of 25 mg / kg of weight. With profuse bleeding (uterine) - for twelve to fourteen days, three doses of 1.5 g. Therapy with an angioedema edema of a hereditary nature for 2-3 doses of 1-1.5 g permanently or under the supervision of a specialist.
Tranexan. Instructions for intravenous administration
Solution for injection use drip, jet.
When strengthening local fibrinolysin 2-3 injections of 250-500 mg are administered, with a general increase, every six to eight hours with a single dose of 15 mg / kg at a speed of 1ml / minute.
In cases of bladder andProstatectomy during the intervention is injected 1 g, then every eight hours for three days. After that, they switch to taking the tablet form of the drug.
Patients with a clotting disorder before the extraction of the tooth are administered 10 mg / kg. After the extraction, tablets are prescribed.
In the presence of violations in the functions of the kidneys, the dosage should be recalculated in accordance with the level of creatinine.
Tranexan. Instructions. Side effects
Diarrhea, nausea, anorexia, vomitingdesires, heartburn are noted from the gastrointestinal tract. Dizziness, drowsiness, visual impairment, color perception, weakness are manifested by the central nervous system. There are pains in the chest, tachycardia, development of thromboembolism, thrombosis and other reactions of the cardiovascular system. With rapid administration, hypotension is likely to occur. The use of the drug also causes hives, skin rash, itching.
Tranexan. Instructions. Contraindications
The drug is not prescribed for hypersensitivity to components, with subarachnoid hemorrhage.
