The value of vitamin B1 (thiamine) for humanorganism is difficult to overestimate. Unfortunately, in modern medicine quite often there are cases when the additional introduction of this substance is simply necessary. It was then that the use of the drug "Thiamine hydrochloride" was shown. What are the properties of the medicine? When is it necessary? These questions interest many patients.
The drug "Thiamine hydrochloride": a brief description
This tool is produced in the form of a solution forintramuscular injection. It is usually colorless (sometimes a slight shade may be present), with a characteristic slight smell. It is placed in ampoules of neutral glass. Available in boxes of 5 or 10 ampoules.
The main active substance in this caseis thiamine hydrochloride. 1 ml of solution contains 50 mg of the main component. The excipients used are purified water for injection, as well as unithiol. By the way, today an analogue of the drug called Benevron is increasingly used.
Main properties of the preparation
Thiamine - a drug that helpsnormalize the work of the whole organism. After all, this vitamin is an indispensable participant in many metabolic reactions. After injection into the muscle, the solution is rapidly absorbed and spreads throughout the body. Its content in the tissues of the liver, nervous system, as well as in the myocardium and skeletal muscles is increased, since its consumption is increased here.
In the body tissues by phosphorylationthiamine hydrochloride is converted to an active coenzyme of certain exchange reactions. This substance is involved in the metabolism of lipids, carbohydrates and proteins. In addition, some forms of thiamine affect the transmission of nerve impulses in synapses. The drug is neutralized in the liver tissues, after which it is excreted by the kidneys along with urine.
Indications for use
In fact, there are a large number of conditions in which it is advisable to introduce an additional amount of vitamin.
- The main indication in this case is vitamin B1 hypovitaminosis or vitamin B avitaminosis. This condition is often observed in people on hemodialysis or tube feeding.
- The drug is also prescribed in the presence of various dystrophic processes that are observed during fasting, intestinal atony, myocardial dystrophy, and severe liver diseases.
- As a prevention of beriberiAn additional amount of thiamine is prescribed to people with increased needs, for example, during the period of intensive and rapid growth, during pregnancy and breastfeeding.
- The drug is also indicated for severe intoxication of the body, including thyrotoxicosis and chronic alcoholism.
- Thiamine helps to cope with some diseases of the nervous system, including various neuralgia, neuritis, paresis and paralysis, radiculitis.
- Some skin lesions, such as psoriasis, dermatosis, eczema and psoriasis, are also considered indications for taking a thiamine solution.
The drug "Thiamine hydrochloride": instructions for use
Of course, you need to startconsult with a specialist - it is the doctor who determines the daily dose and duration of treatment. Thiamine - solution for intramuscular injection. As a rule, therapy begins with small doses of medication. To begin with, no more than 0.5 ml of a 5% solution is injected (this corresponds to 25 mg of the active ingredient). In the event that the drug is well tolerated, the dose is gradually increased.
The recommended amount of thiamine hydrochloride foradult patients is 25-50 mg - they are injected with 0.5-1.0 ml of solution once a day. If we are talking about the treatment of children, then the daily dose, naturally, is less and amounts to 0.25 ml of solution (12.5 mg of thiamine). The course of treatment usually lasts from ten to thirty days.
Стоит отметить, что более предпочтительным is an oral vitamin intake. The solution for injection is used only if taking tablets is not possible, which is observed, for example, during the pre- and postoperative period, as well as with malabsorption syndrome, severe nausea, accompanied by vomiting.
Are there any contraindications?
Actually contraindications to usedrug "Thiamine hydrochloride" is not so much. Naturally, first of all it is worth noting that the medicine is forbidden for people with hypersensitivity to any of the components of the product. In addition, it is not prescribed to patients with thiamine hypervitaminosis. Symptoms of an excess of vitamin B1 include excessive sweating, tremor, shortness of breath, pharyngeal spasm. By the way, hypervitaminosis is extremely rare, since thiamine is a non-toxic substance. The most common cause of hypovitaminosis is an overdose of drugs.
Possible side effects
Fortunately, the drug "Thiamine hydrochloride"almost completely safe. Only rarely can side effects occur, which are reduced to an allergic reaction. In particular, these include urticaria, the occurrence of pruritus and redness. Sometimes there is angioedema. In the most severe cases, anaphylactic shock may develop. If you have these symptoms, you should stop using the medication and contact your doctor as soon as possible.
By the way, at the injection site may occurredness, slight swelling, and soreness are completely normal. It is worth noting that most of the side effects occur in women in menopause, as well as in people suffering from chronic alcoholism.
Overdose and its symptoms
When using too large doses of the drug"Thiamine hydrochloride" overdose is possible. What are her symptoms? In most cases, there is an increase in side effects. However, other symptoms are possible. People who for a long time take too large doses of the solution, often complain of severe headaches. In some cases, tremor occurs, as well as an increase in heart rate. Sometimes there is insomnia and irritability. If you have any concerns, it’s best to go to a doctor right away. An effective antidote to the drug does not exist; therefore, for therapeutic purposes, the administration of the “Thiamin Hydrochloride” solution is stopped and symptomatic treatment is carried out.
Interaction with other drug
Before you start using the medicine you needBe sure to tell your doctor about the drugs that you are taking, as some drugs with thiamine are not combined. For example, the solution should not be used simultaneously with medicines containing sulphides, since they completely neutralize the specified substance. In turn, pyridoxine slows down the process of converting a solution of thiamine into a biologically active form. The simultaneous use of thiamine hydrochloride and cyanocobalamin is prohibited, since it increases the likelihood of an allergic reaction.
Стоит также отметить, что витамин В1 не стабилен in alkaline and neutral solutions, therefore mixing it with citrates, barbiturates and carbonates is not recommended. You can not mix rasters of vitamin and some antibiotics in one syringe, as under the influence of the first antibacterial substances are destroyed. Solution for injection "Thiamine hydrochloride" may weaken the effect of depolarizing muscle relaxants. It is also worth noting that during therapy in no case should you drink alcohol, since ethyl alcohol slows down the rate of absorption of the vitamin.
