What is the preparation "Vilprafen 1000"?The answer to this difficult medical question you will find in the materials of the article. Also from it you will learn how to take this medication, what it is meant for, whether there are side reactions and contraindications, what can be replaced and so on.
Composition, packaging and form of release of a medical device
The preparation "Vilprafen 1000" can be purchased indrugstore in the form of dispersible tablets of white color (can be and with a yellowish shade). They have an oblong form with a risk and the inscription "IOSA" on one side, with the digit "1000" on the other. It should also be noted that this remedy has a sweetish flavor and strawberry flavor.
The active substance of the drug "Vilprafen 1000"is josamycin. As for the auxiliary components, they include aspartame, giprolose, silicon colloidal dioxide, microcrystalline cellulose, sodium docusate, strawberry flavor and magnesium stearate.
In the sale of the drug comes in blisters of 5 tablets, placed in a cardboard box.
Pharmacological action of the drug
What is the medicine "Vilprafen 1000"? Instructions for use of this medication contain information that the drug is an antibiotic belonging to the macrolide group.
The mechanism of action of the medicament in questionis associated with a violation of protein synthesis in microbial cells. This effect is due to the reversible binding of the active substance to the 50S subunit of the ribosome.
In therapeutic volumes, this agentis able to have a bacteriostatic effect, slowing the reproduction and growth of bacteria. If you create high concentrations in the inflammation focus, then a bactericidal effect is possible.
Medication "Vilprafen 1000" shows a specialactivity against gram-positive and gram-negative microorganisms. However, it does not affect enterobacteria. In connection with this, this drug can not negatively affect the state of the gastrointestinal microflora.
In some cases, the drug remains active in resistance to erythromycin, as well as other macrolides.
Pharmacokinetics of the drug
How long is the drug "Vilprafen 1000" absorbed?The instruction of this remedy states that after ingestion the active element of the drug is absorbed rather quickly from the organs of the digestive tract. At the same time, food intake does not affect its bioavailability.
The greatest concentration of the drug is reached about an hour after ingestion. At a dosage of 1 g, the maximum concentration is about 2-3 μg / ml.
The active substance of the drugfairly well distributed to tissues and internal organs (with the exception of the brain). In this case, the medicine creates concentrations that exceed plasma concentrations and persist for a long time at the therapeutic level.
High concentrations of josamycin are observed in the tonsils, lungs, saliva, tear fluid and sweat. The drug easily passes through the placental barrier, and is also secreted in breast milk.
Josamycin (the active substance of the drug) is metabolized in the liver. In this case, active metabolites are formed.
The drug is excreted mainly with bile. But excretion together with urine does not exceed 10%.
Indications for the use of a medical device
When should I use the drugWilprafen 1000? Reviews about this drug, we'll look at a little later. Now I want to tell you that this medicine is prescribed only for infectious and inflammatory diseases that were caused by microorganisms that are sensitive to the drug:
- diphtheria (as an adjunct to diphtheria antitoxin therapy);
- infections of the ENT organs and upper respiratory tract (laryngitis, pharyngitis, otitis media, tonsillitis, sinusitis and paratonzillitis);
- infections of the lower respiratory tract (exacerbation of chronic bronchitis, acute bronchitis, community-acquired pneumonia);
- pertussis;
- scarlet fever (if there is hypersensitivity to penicillin);
- infections of the oral cavity (pericoronitis, gingivitis, alveolitis, periodontitis, alveolar abscess);
- psittacosis;
- infections of soft tissues and skin (furuncle, folliculitis, acne, furunculosis, lymphangitis, abscess, phlegmon, lymphadenitis, panaritium, wound, burn and postoperative infections);
- infections of the eyes (dacryocystitis and blepharitis);
- erysipelas (if hypersensitivity to penicillin is present);
- anthrax;
- infections of the genitals and urinary tract (cervicitis, urethritis, prostatitis, epididymitis);
- lymphogranuloma venereal;
- diseases of the digestive system that are associated with Helicobacter pylori;
- syphilis and gonorrhea (if there is hypersensitivity to penicillin).
Contraindications to the use of medicament
In what cases is it impossible to use the preparation "Vilprafen Solutab 1000"? Experts say that this medication has the following contraindications:
- children with a small body weight (less than 10 kg);
- severe liver disorders;
- hypersensitivity to the active substance;
- increased sensitivity to antibiotic drugs belonging to the group of macrolides.
Medicinal preparation "Vilprafen 1000": instructions for use of the drug
Dosage of this drug should be determined only by the attending physician and only in an individual order.
For adults and teenagers over the age of 14, the usualthe amount of this drug is 1-2 g. It is recommended to take it in 2-3 doses. If necessary, the dose may be increased (eg, up to 3 g per day).
The daily dose for children, whose body weight is not less than 10 kg, is prescribed based on a calculation of 40-50 mg per kg of weight. The medication should be taken 2-3 times a day.
Исходя из вышесказанного, нетрудно подсчитать, that a child with a body weight of 10-20 kg should be given 250-500 mg of the drug twice a day (a quarter or half of the tablet previously dissolved in water).
A child with a body weight of 20-40 kg is given 500-1000 mg twice a day (half or whole tablet dissolved in water).
Children weighing more than 40 kg are prescribed 1000 mg (that is, one tablet) twice a day.
How much should take the drug "Vilprafen"(1000 mg)? The duration of treatment with this agent is determined only by a doctor (usually it is 5-21 days, depending on the severity and nature of the infection).
Scheme of anti-Helicobacter therapy (treatment of stomach ulcers)
Now you know how to take WilprafenSolutab 1000 ". If you need anti-Helicobacter therapy, this medication is prescribed in the amount of 1 g twice daily for 1-2 weeks. In this case, the drug should be combined with other agents in their standard doses ("Famotidine", "Omeprazole", "Omez", "Omez D", etc.).
Dispersible medication can be taken orallydifferent ways. Tablets are swallowed whole (washed down with water) or pre-dissolved in 20 ml of water. In the latter case, before taking it is necessary to mix the resulting suspension thoroughly.
Side effects after using the medication
Analogs "Vilprafen 1000", as well as the drug itself can cause a number of undesirable reactions. Among the side effects most commonly observed are the following:
- Digestive tract: stomach discomfort, abdominal discomfort, nausea, diarrhea, stomatitis, vomiting, constipation, pseudomembranous colitis and loss of appetite.
- Allergy: urticaria, anaphylactoid reaction, exudative erythema multiforme, angioedema, bullous dermatitis, Stevens-Johnson syndrome).
- Biliary tract and liver: jaundice, hepatic dysfunction.
- Sense organs: dose-dependent transient hearing loss.
- Other: purple.
Interaction with other medical devices
Since bacteriostatic antibiotics can reduce the antimicrobial effect of bactericidal antibiotics, it is necessary to avoid their combined use.
Josamycin is strictly prohibited to be prescribed together with lincosamides. This is due to the fact that a mutual decrease in their effectiveness is possible.
Representatives of the macrolide group significantly slow down the elimination of xanthines. This can lead to symptoms of intoxication.
When sharing josamycin and antihistamines containing astemizole or terfenadine, the risk of life-threatening arrhythmias may increase.
There are reports of increased vasoconstriction as a result of the joint use of antibiotics from the group of macrolides and ergot alkaloids.
The joint appointment of cyclosporine and josamycin causes an increase in the level of cyclosporine in the blood, and also increases the risk of nephrotoxicity.
With the combined use of digoxin and josamycin may increase the level of the first in the blood.
Special instructions for use of the drug "Vilprafen 1000"
In the case of severe and persistent diarrhea, it is necessary to bear in mind the likelihood of the development of life-threatening pseudomembranous colitis (while taking josamycin).
In patients with renal failure therapy is recommended based on the results of laboratory tests.
It is necessary to consider the probability of crossresistance to various antibiotic agents belonging to the macrolide group (bacteria resistant to antibiotics related by chemical structure may be resistant to josamycin).
Cost and analogues of the drug
Цена рассматриваемого препарата не очень высока.So, for 10 tablets of the drug you will have to pay about 150 Russian rubles. Agree, this is a fairly low cost, given the effectiveness of the drug "Vilprafen 1000". Analogs are cheaper you are unlikely to find in pharmacies.
If you are contraindicatedmedication, it can be replaced with one of the following drugs: Midecamycin, Roxithromycin, Spiramycin, Clarithromycin, Azithromycin or Erythromycin. These drugs are similar to the active substance. The so-called structural analogues of this medication is not.
Reviews of patients and specialists about the medical device
Today there are quite a fewpositive reviews about this medication. Patients who have ever taken this drug, note its rapid therapeutic effect, which is noticeable after taking the first dosages. This is especially observed with such deviations as sore throat, otitis media, sinusitis and cystitis.
Side effects after taking the drugfunds are observed quite rarely. Some reviewers report stool disorder, as well as occasional nausea. By the way, these unpleasant effects spontaneously disappear within a few days.
It should also be noted that a large number of patients are pleased with the price of this drug.
According to experts, the possibility of treatment with the drug "Vilprafen" during pregnancy.
