The drug "Metrogil" (intravenously) refers toantimicrobial and antiprotozoal agents. The active substance of the drug is metronidazole. The drug shows its activity against a number of gram-positive bacteria, obligate anaerobes. In combination with amoxicillin Helicobacter pylori acts. Resistant to the drug exhibit facultative anaerobes, aerobic microorganisms. The drug increases sensitivity to irradiation of tumors, provokes disulfiram-like manifestations, stimulates repair processes.
The medicine "Metrogil" (for intravenous administration). Pharmacokinetics
With an infusion of 500 mg for 20 minutesthe maximum content of the drug in the blood is noted in an hour. Metabolism is subjected to about 30-60% of the drug. The main metabolite has antimicrobial and antiprotozoal effects. About 60-80% leaves with urine, with feces it is deduced up to 15% of a medicine.
Appointment
The drug is indicated for treatment and preventionInfectious lesions caused by sensitive microbes. In particular, the drug is recommended for surgical interventions in the urinary tract and abdominal organs. The indications should include sepsis, hepatic and intestinal amebiasis in severe form, osteomyelitis, abscesses of the brain, small pelvis. The medication "Metrogil" (intravenously) is prescribed for lesions of soft tissues, skin, bones, articular infections, gynecological pathologies. The drug is recommended for radiotherapy of tumors (as a radiosensitizing agent in cases of neoplasm resistance caused by hypoxia in its cells).
Application Scheme
Initial dosage for patients from 12 years of age - fromhalf to one gram of drip. The duration of the infusion is thirty to forty minutes. Each subsequent 8 hours, the drug is administered 500 mg each. The infusion rate was 5 ml / min. With satisfactory tolerability, after 2-3 first infusions, a jet injection is used. The duration of therapy is a week. A day is allowed not more than 4 g. Patients under 12 years of age, Metrogyl (intravenously) are prescribed according to this scheme in a single dose of seven and a half milligrams per kilogram. For the prevention of complications during surgical interventions, patients with 12 years of age are prescribed before surgery from 0.5 to 1 g per day and on the following day for 1.5 g / day. (0.5 mg every 8 hours). When used as a radiosensitizing agent, administration is carried out dropwise at 160 mg / kg or 4 to 6 g / m2 surface of the body. The infusion is performed half an hour before the irradiation.
Side effect of the drug "Metrogil" (intravenously). Reviews
As practice shows, while observing the speedinfusions and dosing regimens, undesirable effects rarely develop. According to the specialists, the patients tolerate the therapy satisfactorily. Seldom there can be infringements in activity GASTROINTESTINAL TRACT, nervous system. On the basis of hypersensitivity, the development of an allergic reaction is likely. Some patients had convulsions, hallucinations, impaired appetite, a taste in the mouth of the metal.
