Among antimicrobial agents for systemicuse of doctors often when prescribing drugs stop their choice on the drug "Cefazolin." The composition of this drug includes sodium cefazolin, a semisynthetic cephalosporin antibiotic of the first generation. A medicine is produced in the form of a white powder for making a solution for injections.
Characterizing the active component of the drug Cefazolin (injections), the instruction indicates its activity against many microbes (Gram-negative, Gram-positive).
Immediately after intramuscular injection, a rapidsuction. Up to 90% of the applied dosage is associated with proteins in the blood plasma. The concentration reaches a maximum after 1 hour after intramuscular injection and immediately after intravenous injection.
The drug is able to penetrate quite wellfluid and tissue through the synovial membrane in the joints and abdominal cavity. The therapeutic concentration of the drug persists in the blood for eight to twelve hours.
Cefazolin. Indications for use
The drug is prescribed for infections that areprovoked by microorganisms sensitive to the active component. These include infectious pathologies in the respiratory tract (pneumonia, bronchitis), in soft tissues and skin, the genitourinary system (urethritis, cystitis, prostatitis, pyelonephritis), bile ducts, bones and joints. Cefazolin (injections) instruction recommends for endocarditis, for prophylaxis during surgical interventions (hysterectomy, open heart surgery, joints, bones, cholecystectomy and others).
Introduction is carried out by jet or drip intravenously or intramuscularly.
Application for infections, provokedGram-positive microbes, adults are prescribed 0.5 or 1 g per day 3-4 times. In conditions of moderate severity, cefazolin (injections) allows the instruction to be administered twice a day. On average, the amount of the drug is 1-4 g, the maximum dosage is 6 g per day.
In the prevention of postoperative complications,purulent-septic including, the drug is administered intravenously or intramuscularly for half an hour before the operation. For prolonged interventions (two or more hours), re-inject 0.5 to 1 g of the solution. After the operation, the drug is used (intravenously or intramuscularly) for a day every six or eight hours for 0.5-1 g.
The use of medication can cause itching,rash, eosinophilia, angioedema, erythema multiforme, fever, anaphylactic shock. In rare cases, nausea, abdominal pain, vomiting, candidiasis, diarrhea, and sometimes pseudomembranous colitis are possible.
In patients with impaired renal function, nephropotoxicity may occur.
Cefazolin (injections): instructions, contraindications
The agent is not prescribed for lactation,hypersensitivity to antibiotic preparations of cephalosporin series and other beta-lactam drugs (antibiotics), during pregnancy. Patients under one month, prematurely including, are prescribed cifazolin only in the presence of vital indications.
Overdose of cefazolin in patients withdeficiency of renal function in a chronic course can cause neurotoxic phenomena. There is also tachycardia, vomiting, clonic-tonic convulsions of generalized nature, increased vascular alertness. Removal of the drug from the body is carried out with hemodialysis. Probably the occurrence of an allergic reaction. In this case, cefazolin is discontinued, desensitizing therapy is administered.
To use only clear solutions prepared immediately before administration are allowed.
When prescribing the drug, children are recommended to take probiotics.
Before using Cefazolin, you should consult your doctor for possible side effects, identify the presence or absence of contraindications.
