Lozap Plus is supplied in the form of coated tablets, of light yellow or pale color. The tablets have an oblong shape and share the risk on one side.
Composition
Active substances:
- hydrochlorothiazide - 12.5 mg (in 1 tab.);
- losartan - 50 mg (in 1 tab.)
Excipients:
- macrogol 6000;
- microcrystalline cellulose;
- mannitol;
- sodium crosparmellose;
- magnesium stearate;
- povidone;
- hypromellose;
- talc;
- dye;
- simethicone emulsion.
pharmachologic effect
Лозартан – это антагонист рецепторов ангиотензина 2, which does not suppress kinase 2. The drug reduces the round, blood pressure, blood levels of aldosterone and adrenaline. In addition, the drug successfully has a diuretic effect and reduces afterload.
Losartan can prevent the development of such pathologies as myocardial hypertrophy, as well as increase the resistance of patients who take this drug to heart failure.
Hydrochlorothiazide belongs to the thiazide diuretic group. It reduces the reabsorption of sodium and increases the excretion of potassium, phosphate and bicarbonate with urine.
The antihypertensive effect can reach its maximum in 3 weeks.
Indications
- arterial hypertension in a patient;
- reducing the risk of developing CVD in patients with advanced left ventricular hypertrophy and arterial hypertension
Side effects
Side effects of lozap plus are described in the instructions based on the side effects of its main active ingredients - losartan and hydrochlorothiazide.
Side effects that affect the central nervous system
- dizziness (quite often).
Side effects that provoke allergic reactions of the body:
- angioedema;
- laryngeal edema (and other parts of the upper respiratory tract);
- hives;
- vasculitis;
- Schönlein-Henoch disease.
Side effects that affect the cardiovascular system (cardiovascular system):
- arterial hypertension.
Side effects that affect the digestive tract (risk of less than 1%):
- hepatitis;
- diarrhea;
- increased liver transaminase activity.
Adverse effects that affect the respiratory tract:
- cough.
Side effects that affect the water-electrolyte balance (risk of less than 1%):
- hyperkalemia.
Contraindications
- arterial hypertension;
- anuria;
- hypovolemia;
- impaired renal function and liver;
- age to 18 years;
- sensitivity to components;
- pregnancy;
- lactation.
If the patient’s pregnancy happened in the backgroundconsumption of the drug, it should be immediately canceled. The fact is that a lotion plus directly affects the renin-angiotensin system, which can lead to fetal death in the last two trimesters of pregnancy.
Pills "Lozap plus" take pregnantPatients are not recommended because the drug can cause jaundice in the newborn, as well as thrombocytopenia in the mother. Therapy carried out with the help of diuretics, in this case will not help to avoid toxicosis.
Overdose
Symptoms of drug overdose:
- decrease in blood pressure;
- bradycardia;
- tachycardia;
- dehydration (due to increased diuresis).
Treatment of drug overdose is necessarystart with gastric lavage in the event that the patient has taken the lozap plus relatively recently. After that, the patient is supposed to have symptomatic treatment, and in other cases - correction of water and electrolyte disorders. Hemodialysis will not be able to remove both losartan and its metabolites.
Drug Interactions
Lozap plus potentiates the actions of the restantihypertensive drugs in the case of their complex use. The drug may also cause potentiation of orthostatic hypotension, if used in conjunction with barbiturates.
