In recent years, more and more representativesthe weaker sex who are at reproductive age suffer from endometriosis. This is a very unpleasant hormonal disease that requires complex correction. Often, an antitumor drug is used to eliminate it. However, the greatest effect will be achieved with additional surgical intervention.
This article will tell you about the drug."Buserelin Depot". Reviews with endometriosis about him there are different. Opinions of some patients will be described below. You will also find out what the doctors think about this drug. It is worth saying that informs the consumer about the composition of "Buserelin depot" instruction.
In what form is the medicine produced?
About drug "Buserelin depot" instructionsays that the drug has two main types - spray for nasal use and lyophilisate for intramuscular administration. In this case, the second type of medication must be pre-diluted before use. The method of application is always described in detail in the instructions attached to the medication.
The active ingredient of the drug is buserelin acetate. Depending on the form of release in the product, there may be additional components.
What is the price of Buserelin Depot?The cost of the drug also varies depending on the type of drug. Nasal spray will cost you 800-900 rubles per bottle of 17 ml. If it is necessary to purchase an injection of the medicine "Buserelin depot", the price of one ampoule with a device for administration will be about 4,000 rubles.
What is this medicine? Description of the action of the drug
The antitumor drug "Buserelin depot" isgonadotropin releasing hormone. It is abbreviated as GnRH. Also from the doctors you can hear the designation gonadorelin and others. To somewhat clarify the situation, it is worth saying that this class of hormones is stimulating. Gonads are testes. In other words, the spray or injection of "Buserelin Depot" affects sex hormones.
The drug actively stimulates the front dose.pituitary gland. Under its action, the production of two main substances is shut off - follicle-stimulating and luteinizing hormones. Without these components in the woman’s body, ovulation is completely blocked. In the treatment with the described agent, there is a decrease in plasma estradiol to post menopausal values.
Indications for use of the drug: what the instruction informs
About medicine "Buserelin depot" instructions forapplication says that this composition is appointed in the event that a woman has an excess of estrogen in the body. Often such a hormonal disorder leads to the development of endometriosis and the formation of uterine fibroids. Also, the drug is sometimes used among the stronger sex. On the drug "Buserelin depot" instructions for use says that the drug is strictly forbidden to use on their own. Prescribe the drug and choose an individual scheme of use should be a specialist. Otherwise, very unpleasant consequences of improper treatment may develop. The annotations indicate the following conditions when it is necessary to apply the described remedy:
- benign ovarian tumors (follicular and luteal cysts);
- endometriosis and endometriomas;
- uterine fibroids of various sizes and types;
- endometrial hyperplastic transformations;
- preparation for surgery for fibroids and endometriosis;
- prostate cancer or suspicion of it;
- infertility treatment and so on.
The drug is often combined with other methods of treatment (laparoscopy, laparotomy, hysteroscopy, mobilization of arteries in the uterus, and so on).
What are the contraindications to the use of the drug?
Treatment with Buserelin Depot is possible only afterthorough examination and diagnosis of blood levels of hormones. Also, a woman is recommended to pre-make an ultrasound of the pelvic organs In some situations, additional research manipulations are shown.
The composition is strictly prohibited to apply whenpregnancy and breastfeeding. It is known that this drug is able to penetrate into breast milk. Consequently, the medicine will affect not only the woman, but also her baby. The drug is contraindicated in the period of childbearing due to teratogenic effects on the fetus. Such a correction may lead to abortion or delayed embryo development.
The medicine is prohibited for use in girls, notreached puberty. The use of the medication may adversely affect their future hormonal background. It is also impractical to prescribe the composition of women during menopause. After all, these representatives of the weaker sex and so does not occur the production of the above hormones.
With increased sensitivity to the componentsdrug is not used. The composition with extreme caution should be used in the period of depression, with diabetes. Also, arterial hypertension may worsen after such treatment.
Nasal Spray Method: Dosage and Scheme
What do reviews say about Buserelin Depot?For endometriosis, spray is very convenient. Women who are afraid of injections and want to save, choose this option. Consumers note that the described drug is several times cheaper than ampoules for intramuscular administration.
900 mcg administered for the treatment of endometriosismedicines per day. This portion should be divided into three steps. One spray contains 150 μg of the drug. Based on this, we can draw the following conclusion. The drug is administered by spraying into each nasal passage three times a day.
Consumers report that before usethe medication needs to clear the nose. To do this, you can use any convenient means (shower, spray, washing). Use of the described substance during rhinitis is allowed. The duration of therapy is up to 6 months.
The disadvantage of this release form is thatit must be taken after a certain time without any deviations from the rules. So, between each injection of the drug should take from 6 to 8 hours. Doctors advise when using the spray in advance to consider the mode of its use and stick to it.
Injections: method of use of the drug in ampoules
«Бусерелин-депо» применение может иметь в виде injection. In this case, the injection is exclusively intramuscular. Other drug administration is unacceptable. Before using the composition must be prepared. Detailed instructions are attached to each ampoule. However, to get proper treatment, you should consult a doctor and administer medication in a hospital.
It is necessary to prepare the suspension withspecial solvent. At the same time, it is inserted with a needle with a red or pink pavilion. After mixing the substances you need to shake them well and wait for some time to obtain a homogeneous liquid. Next, type in the syringe. The peculiarity of this manipulation is that you do not need to turn the ampoule. The syringe after filling is removed from the red needle and inserted into the green one. Existing air bubbles are released and immediate injection is carried out. It is preferable to use the gluteus muscle for the injection. Pre-wipe the skin with an alcohol wipe. In extreme cases, it is allowed to inject the medicine into the leg muscle. However, this should be appropriate testimony.
The duration of therapy is from 3 to 6.months. If necessary, it may be longer. The injection is placed once every 4 weeks. Women say that it is much more convenient than three times a day to spray the composition on the nasal mucosa. However, this correction will be more expensive.
Buserelin Depot: side effects of treatment. What do women feel?
The described drug is rarely well tolerated.In most cases, it always causes adverse reactions. The composition may affect each patient in different ways. That is why you should not be equal to your friends who endured such treatment and complained about certain reactions.
Наиболее часто после «Бусерелина-депо» у женщины menstruation stops. At the same time, physicians indicate that it is rather not a side effect, but a favorable effect of treatment. The composition of its work blocks the production of basic sex hormones. As a result, the endometrium simply does not grow, ovulation does not occur, the cycle phases do not change. Menstruation is usually absent for as long as the treatment lasts.
The action of Buserelin Depot is often accompanied byall the symptoms of menopause and menopause. A woman can feel hot flashes, frequent mood changes, decreased libido. Also, the representatives of the weaker sex have reported an exacerbation of the depressive state, increased headaches. That is why during the period of treatment the patient needs psychological help.
Less commonly, the drug may cause hearing problems andeyesight. Patients note a feeling of pressure on the eyes, tinnitus, and a feeling of discomfort. If you previously had problems with heart and blood pressure, then they can worsen. Some consumers report an allergic reaction to the described remedy. It can be expressed by urticaria, itching, and anaphylactic shock. In such situations, the drug must be replaced with any other analogue.
The composition may provoke weight gain, indigestion, deterioration of the hair. Nasal solution sometimes causes bleeding, dryness and itching in the nose.
"Buserelin Depot": reviews for endometriosis
Women with this diagnosis are often used.described medicine prescribed by a doctor. They note that the cost of the drug is not as high as it seems at first glance. The Buserelin Depot compound has analogues that also treat endometriosis. For example, the drug "Zoladex". However, its cost is much higher. One ampoule will cost you the price of three ampoules of the Buserelin Depot.
Many women with advanced diseasesuffer from infertility. They can not get pregnant because of unstable hormonal levels. Also, the absence of children is explained by the presence of a strong adhesive process in the pelvis. Often, miraculously, the onset of pregnancy begins to develop in the abdominal cavity or fallopian tube. The use of the described medication allows for artificial insemination in childless couples. In this case, the woman first takes "Buserelin" during the cycle, after which the ovaries are over-stimulated. Representatives of the weaker sex say that after pregnancy and prolonged lactation (assuming no menstruation), the disease can subside completely.
Patients say that when usingmedication "Buserelin depot" quickly disappears all the symptoms of endometriosis. Stops the pain, hemorrhage. After all, a patient with such hormonal disorders never knows what time to wait for the next menstruation. Breakthrough "chocolate" bleeding strongly knock with the usual rhythm of life. Also, patients say that Buserelin helped them get rid of the constant pain that always accompanied sexual intercourse.
Безусловно, лечение часто приводит к побочным reactions. Women feel strong discomfort, hot flashes, they sometimes grow stout. During the correction period, there is a deterioration of health If the goal of the patient is to give birth to a child, then depression on this issue can greatly aggravate. The representative of the weaker sex in the period of correction must necessarily enjoy the support of their relatives and friends. Women who have undergone a similar therapy say it is worth it. However, an integrated approach will be more effective. We learn that gynecologists think about this.
What do doctors say about the described treatment?
The drug "Buserelin depot" reviews of doctors hasthe following. Doctors say that the medicine is quite effective. During treatment, the extinguishing of enduring foci of endometriosis occurs. However, as soon as treatment is completed, the problem may return. That is why gynecologists advise to conduct a comprehensive treatment.
If drug therapy is combined withsurgical intervention, you can get very good results. Most often, doctors prescribe the described medication for two months. After this operation is performed (often laparoscopy). By that time, the foci of endometriosis become much smaller, which means that the treatment will be minimally traumatic. After the intervention, hormonal correction continues for another 4-8 months. Projections for this approach are very good. In most cases, the woman stops worrying about her usual symptoms, since adhesions and foci of endometriosis are removed, and hormonal treatment does not allow them to form again.
Small summing up
Вы узнали о блокаторе половых гормонов с торговым name "Buserelin Depot". Reviews for endometriosis medication has positive and negative. Those women who undergo correction may speak negatively about the drug. After all, they have the full effect of side effects. Many representatives of the weaker sex do not withstand therapy and leave the treatment halfway. Positive opinions are expressed by those patients who were able to gain strength and complete such a difficult treatment. They began to feel much better, all the disturbing signs were gone.
Doctors say that the drug "Buserelin depot"is one of the most effective tools that help cope with endometriosis. The remedy affects the problem from the inside. It blocks the production of estrogen, which provoke a large number of growth foci. Patience you in treatment and good health!
