What is the drug "Amoxiclav"?What helps this tool? Answers to these and other questions you will learn from the materials of this article. We will tell you about how much this medicine costs, in what form it is made and whether it can be combined with alcohol.
Composition, shape and packaging
The drug "Amoxiclav" (1000 mg) contains such active substances as the potassium salt of clavulanic acid and amoxicillin trihydrate. It is currently available in the following forms:
- film-coated tablets;
- powder for the preparation of suspensions;
- lyophilized powder for injection.
Amoxiclav tablets (1000 mg) are packed in aluminum blisters and cardboard packs, respectively.
Powder for the preparation of suspensions can be purchased in bottles of dark glass. Also attached to the drug measuring spoon.
As for the injection form, it is available in bottles of 1.2 and 0.6 g, which are placed in cardboard boxes.
Pharmacological features
How does the drug Amoxiclav? Instructions, reviews report that the combination of clavulanic acid and amoxicillin is unique in its own way.
Amoxicillin causes the death of bacteria by binding themsurface receptors. However, most microorganisms have learned to destroy this antibiotic substance by the enzyme beta-lactamase. The activity of this enzyme is able to reduce clavulanic acid. Due to this effect, suspension, injection and Amoxiclav tablets (1000 mg) are used to treat many infectious diseases.
Properties of the medicament
What properties do antibiotics have? "Amoxiclav" (1000 mg) even kills strains of bacteria that have already shown resistance to amoxicillin.
The drug under consideration has a pronouncedbactericidal and bacteriostatic effects on all types of echinococcus, streptococcus and listeria (except methicillin-resistant strains). Also such gram-negative bacteria as Brucella, Bordetella, Gardnerella, Salmonella, Klebsiella, Proteus, Moraxella, Clostridium, Shigella and others are sensitive to this medicine.
Pharmacokinetics
Can I take the drug "Amoxiclav" (1000mg) with food? Regardless of food, this medicine is well absorbed from the intestines. Its greatest concentration is reached already after 60 minutes. It has a high rate and volume of distribution in the body (in the tonsils, lungs, synovial and pleural fluids, fat and muscle tissue, prostate gland, middle ear and sinuses).
In the mother's milk, this drug comes in small quantities.
Amoxicillin is partially destroyed in the body, and clavulanic acid is extensively metabolized.
Displays medication through the kidneys, as well as the lungs and intestines. Its half-life is 90 minutes.
The drug "Amoxiclav": from what helps?
The considered antibiotic is prescribed for the treatment of various infectious diseases:
- airways (for example, chronic or acute sinusitis), inflammation of the middle ear, pharyngeal abscess, tonsilpharyngitis, bronchitis, pneumonia, and others;
- gynecological infections (septic abortion, endometritis, salpingitis, etc.);
- urinary tract (pyelonephritis, cystitis, urethritis, etc.);
- bone infections;
- odontogenic infections, in which the pathogen enters the human body through cavities in the teeth;
- genital infections (gonorrhea, chancroid);
- connective tissue infections;
- inflammation of the biliary tract (for example, cholecystitis, cholangitis);
- infections of the skin and soft tissues (phlegmon, bites, wound infections).
Contraindications for use
Does the antibiotic have contraindications?"Amoxiclav"? Treatment with this tool is not carried out with impaired liver and jaundice (cholestatic), as well as with increased sensitivity to the substances of the drug or to all penicillins.
This drug is prescribed with particular caution if you are allergic to cephalosporins, liver failure, pseudomembranous colitis, and severe renal dysfunction.
In patients with lymphocytic leukemia or mononucleosis, who have been prescribed ampicillin, an erythematous type rash may appear. With such a reaction, the antibiotic should be canceled.
The drug "Amoxiclav": doses and methods of use
The drug "Amoxiclav" may be assigned to patients in different ways. The method of its use depends on the weight and age of the patient, the condition of the liver and kidneys, as well as the severity of the infection.
The best time to useThis medication is the start of the meal. The duration of therapy with this drug is 6-14 days. Do not use the medication longer than the specified period.
Children under the age of 12An antibiotic is prescribed at the rate of 40 mg per kg of body weight per day. Adolescents whose weight is more than 40 kg, the drug is given in the same dosage as adults.
For adults, 375 mg tablets are prescribed everyeight hours, and the drug 625 mg - every 12. For severe infections, the patient is advised to take medicine at a dose of 625 mg (every eight hours) or 1000 mg (every 12 hours).
Doctors stress that Amoxiclav tablets may differ in the number of active ingredients. Therefore, it should be borne in mind that it is prohibited to replace the dose of 625 mg with two doses of 375 mg.
For the treatment of odontogenic infections, use the following scheme: the drug at a dosage of 375 mg is prescribed every eight hours, and at a dose of 625 mg - every 12.
If you want to take medicine for patients with kidney disease, then be sure to take into account the content of creatinine in the urine. People with liver pathologies should constantly monitor its work.
Как следует давать маленьким детям препарат "Amoxiclav"? Suspension, the price of which is not very high, is assigned to babies up to 3 months. The dose of this medicine is determined using a measuring spoon or pipette. For each kg of child's weight should receive 30 mg of amoxicillin. Take medication twice a day.
For children older than 3 months with an average and mild disease, the drug is prescribed at the rate of 20 mg per kg of weight.
How do Amoxiclav being used in severe infections?Suspension (the price of the drug will be listed below) children are assigned in the amount of 40 mg per kg of weight. The same dose is also used to treat deep infections (for example, in inflammation of the middle ear, bronchitis, sinusitis, pneumonia, etc.).
The maximum daily dose of amoxicillin for children is 45 mg / kg, and for adults - 6 grams. As for clavulanic acid, it can be taken per day for a maximum of 10 mg / kg for children and 600 mg for adults.
Side effects
As a rule, the drug "Amoxiclav" is transferredgood enough. Although in some cases, side effects occur in older people and those patients who take medication for a long time.
Most often, adverse reactions occur during or after completion of therapy. Although sometimes their development is observed after a few weeks after treatment:
- diarrhea, flatulence, nausea, glossitis, vomiting, pseudomembranous colitis, dyspepsia, stomatitis, discoloration of the tongue, gastritis, enterocolitis;
- anemia (hemolytic), agranulocytosis, eosinophilia, reduction in platelet and leukocyte counts;
- dizziness, headaches, inappropriate behavior, agitation, insomnia, hyperactivity, convulsions;
- an increase in liver function tests, an asymptomatic increase in the activity of AST, ALP and ALT, as well as the level of bilirubin in the blood;
- rash, erythema multiforme, urticaria, exfoliative dermatitis, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis;
- blood in urine, interstitial nephritis;
- oral candidiasis, fever, candidal vaginitis (with prolonged use of the drug).
Compatibility with other drugs
It is undesirable to combine "Amoxiclav" and indirect anticoagulants, as this may contribute to an increase in prothrombin time.
The medication in question enhances the toxicity of Metatrexate.
The interaction of allopurinol and "Amoksiklava" causes the risk of exanthema.
It is forbidden to prescribe medication together with macrolides or tetracyclines, as well as with sulfonamides due to the decrease in its effectiveness.
You can not combine rifampicin and amoxicillin, as this preprata antagonists. Their combined use reduces the antibacterial effect of both.
Taking this medication reduces the effectiveness of oral contraceptives.
It should also be noted that the drug "Amoxiclav" (1000) and alcohol is prohibited to combine because of the possible increase in adverse reactions.
Price, synonyms and analogues
Synonyms for this drug are: "Clavocin", "Augmentin" and "Moxiclav". As for analogs, they include:
- "Amovikomb"
- "Ecoclav",
- "Arlet",
- "Flemoklav",
- "Baktoklav"
- "Tormentin",
- "Klamosar",
- "Rapiklav",
- "Verclave"
- "Ranklav",
- "Medoclav",
- "Panklav",
- "Liklav".
How much is the antibiotic "Amoxiclav"? Its price depends on the form of release. Tablets (1000 mg) can be purchased for 480 rubles, the suspension - for 280, and the lyophilized powder for injection - for 180.
Drug reviews
According to patient reviews, this medicationis an effective drug that is used to treat many infectious diseases. When taking medication for the treatment of respiratory ailments, relief comes on the third day.
Also, the drug is actively prescribed for the treatment of urinary infections.
Besides the positive reviews about this antibiotic,patients leave and negative messages. According to them, the drug "Amoxiclav" causes many side effects, which manifest themselves in the form of nausea, diarrhea and vomiting.
