The drug "Valdoksan" instruction indicatesproduced in the form of tablets, each of them contains 25 mg of the active substance - agomelatine. The drug belongs to the clinical and pharmacological group of antidepressants.
Pharmacological action is based onAgomelatine's ability to intensively release dopamine and norepinephrine directly in the area of the cerebral cortex. At the same time, the number of extracellular serotonin does not change.
The drug "Valdoxan" improves the condition of patients suffering from chronic stress of moderate severity, a sense of despair and helplessness. Normalizes desynchronization of circadian rhythms.
Tablets "Valdoxan" (analogues of the active substance are drugs "Agomelatine" and "Melitor") helps to restore the naturalsleep patterns, the formation of melatonin and additionally lower body temperature. Sustained positive dynamics is observed in patients with prolonged depression after 6, 8 weeks of taking the drug with a daily dosage of 25 mg to 50 mg.
In the course of clinical studies, a stable therapeutic result was established in patients with complex depressive disorders who took the anti-depressant Valdoxan at the recommended doses.
The instruction indicates that this remedy is notimpairs memory functions, concentration, when dosing 25 mg increases the phase of slow sleep, without changing the number of phases of REM sleep, their duration. Additionally, the active substance contributes to the treatment of disorders of the sexual sphere, normalizing the arousal phase and orgasm. The weight of the patients did not increase, the blood pressure parameters remained unchanged, the drug did not affect the heart rate. After the abolition of agomelatine feeling of addiction does not occur.
Medicine "Valdoxan", instructions, indications
The doctor prescribes a drug for the treatment of major depressive disorders in adults.
Dosing
Tablets are for oral administration.use 1 time before going to bed. At the beginning of the treatment, the doctor recommends taking 1 tablet of Valdoxan, which is 25 mg of agomelatine, calculated on the active substance. If the clinical picture does not improve after a two-week intake, the dose is increased to 2 tablets, which means 50 mg of the drug.
During therapy, it is necessary to monitor the liver. The drug is intended for a long course of treatment, lasting up to 6 months, until the cessation of all symptoms of a depressive state.
Side effect of medication "Valdoksan"
The difficulty of determining side effects withdrug treatment is that it is difficult to distinguish between symptoms of the disease and the negative effects of therapy. The most frequent side effects that occur during treatment are nausea and dizziness, which quickly disappear. In the vast majority of cases, discontinuation of the drug is not required.
Among the disorders in the nervous system there are data on headache, drowsiness, insomnia, migraine, paresthesia.
Among mental disorders there is evidence of the occurrence of anxiety, agitations, mania, suicidal behavior, although such signs may be a manifestation of the disease.
Among the disorders in the digestive system there is evidence of nausea, diarrhea, constipation, and abdominal pain.
Possible violations in the hepatobiliary system.
Among other abnormalities in the body there is evidence of sweating, eczema, itching, rash, visual disturbances, back pain and general fatigue.
Contraindications
It is impossible in some cases to prescribe the drug "Valdoxan". The instruction contains a list of conditions in which the use of this therapeutic agent is contraindicated:
- with hepatic insufficiency;
- in combination with strong inhibitors of isoenzyme CYP1A2;
- for children under the age of 18;
- for patients with lactose intolerance;
- in case of hypersensitivity to one of the components of the drug.
The drug "Valdoxan" and alcohol are incompatible. In the appointment of the drug in elderly patients should be extremely careful.
