Aromatase inhibitors, or blockers, are a kind ofmedicinal agents that are used to reduce the concentration of estrogens in the blood and increase the level of gonadotropic hormones and own testosterone. These substances are also used to treat and prevent male gynecomastia.
Aromatase inhibitors in bodybuilding are very often used during the course of anabolic steroids course for:
- an increase in the levels of anabolic hormones in the blood;
- prophylaxis of gynecomastia;
- prevention of hypertension;
- increased relief (by eliminating the negative effect of estrogens);
- reduction of estrogenic destruction of the axis of the testicle-pituitary-hypothalamus, which leads to an early reconstruction.
Building a course, it is necessary to reckon with the fact thatNot all anabolic steroids are susceptible to aromatization. Use is justified with the use of products such as methandrostenolone, methyltestosterone, testosterone and its derivatives. Slightly flavored halotestin, boldenone.
Efficiency
The most accessible and preferred aromatase inhibitors (in terms of fruitfulness are almost similar):
Product (world-wide name) | Trademark (sold by pharmacies) | approximate price | Form of issue | Preventive use in bodybuilding | When gynecomastia occurs |
«Exemestane» | Aromazine | 1600 rubles. | 30 tab. By 25 mg | 2.5 mg (1/2 tablet) every other day | 25 mg daily until elimination of symptoms. Then reduce the dosage to preventative. |
Letrozole | Letromara (Pharmac.) Letroza "Estrolet" | 3200 rub. 1000 rubles. | 30 tab. 2.5 mg | 0.5 mg (1/5 tablet) every other day | 2.5 mg daily until elimination of symptoms. Then reduce the dosage to preventive. |
"Anastrozole" | Selana Egistrazole Anastrozole Kabi | 1500 rubles. 350 rubles. 1300 rub. | 28 tab. 1 mg each | 0.5 mg (1/2 tablet) every other day | 1 mg daily until elimination of symptoms. Then reduce the dosage to preventative. |
It should be noted that a moderate concentrationestrogen is useful for muscle growth, so preventive dosages are indicated in the volumes that affect the maintenance of the physiologically necessary level of male estrogens.
Use on the course
Most domestic athletes, applyinginhibitors of aromatase, use the following tactics: drugs are used only when the first signs of gynecomastia (itching in the nipple, swelling, redness) appeared. Unfortunately, this approach can not be called optimal.
The most rational decision isTesting of estradiol after about ten days of using anabolic steroids with a short half-life (Methandrostenolone, Testosterone Propionate) or after three to four weeks of using elongated esters (Sustanon, Enantat, Cypionate). Further, the average portion of "Anastrozole" is prescribed - 0.5 mg every other day. After ten days, a control analysis of estradiol is carried out and the dosage is adjusted according to the results.
A compromise option is the use oflow and moderate portions of "Anastrozola", focused on personal impressions. If after such treatment there is depression, a breakdown in erectile function, a drop in libido, then you need to lower the dose.
Research
The emergence of a publicly available trademarkLetrazol has brought this product to the forefront. There are many tests that prove the high efficacy of this remedy in men. The introduction of the substance was accompanied by a marked increase in gonadotropin (LH). The productive dosage starts at 0.02 mg (below the therapeutic dose by 100 times): with it one can reduce the concentration of estrogen by a third. 50% of Letrozole is excreted from the body for 2-4 days, which allows it to be drunk every other day. The basic disadvantage is his ability to reduce the level of estrogens even by small dosages.
"Anastrozole" is popular in bodybuilding:He was remarkably studied on men as a means of reducing estradiol. Experienced it was shown that a dose of 1-0.5 mg can reduce the level of estradiol by approximately 50%. Dealers can buy this product almost ten times cheaper than in the pharmacy. In megacities, there is a cheap "Anastrozol Kabi".
In his book, Dr. Mauro G.De Pascale wrote: "It is assumed that estrogens, formed as a result of the aromatization of testosterone and other anabolic steroids in the hypothalamus and brain, reduce the secretion of luteinizing hormone, and, consequently, the production of testosterone." Gilmann and Hudmann inform that the feedback is activated more by the accumulation of estrogens than testosterone. In this way, it is explained that aromatase inhibitors can significantly reduce the inhibitory effect of anabolic substances on the release of personal sex hormones.
Third-party effects
What are the dangerous aromatase inhibitors for men?We know that estrogens in small doses have a positive effect on the male body. Estrogen hormones increase both the effectiveness of the course, and the susceptibility of androgen receptors. In addition, they themselves have a protective and anabolic effect.
The importance of muscle estrogen receptorsthoroughly described in the thesis of Anna Wiik. In fact, in fact, impressive doses of blockers can unnecessarily reduce the level of estrogen, which contributes to the occurrence of such side effects as:
- inhibition of muscle growth;
- joint pain (arthralgia);
- deterioration of well-being and a drop in libido;
- depression;
- lipid profile disorder (increased cholesterol);
- decrease in strength of bones.
Subjectively, drugs are better tolerated than "Tamoxifen".
Natural inhibitors
The following are distinguished:
- caffeine;
- resveratrol;
- zinc;
- nicotine;
- apigenin;
- catechins;
- Eriodictiol.
Application of "Anastrozole"
What else are aromatase inhibitors good for?Drugs data are widely used in bodybuilding. For example, "Anastrozole" is necessary to delay water in the human body and prevent the occurrence of gynecomastia (often in combination with androgens such as testosterone and dianobol or in combination with finasteride). But in this case, the athlete also receives an impressive set of forbidden preparations from the "List of prohibited methods and substances", moreover, they have their own spectrum of secondary effects.
Uncontrolled application of "Anastrozole" by athletes,fond of, in particular, bodybuilding, can lead to arthralgia, asthenia, or to a decrease in mobility of the joints, headache, drowsiness. Of course, occasionally there may be thromboembolic problems and develop strokes.
About "Anastrozole" a lot is written in the literature forathletes as a very harmless drug. But the distant and immediate effects of its reception can be the most unpredictable and tragic. After all, if you take only one tablet (1 mg) daily, you can get a pronounced hormonal surge. By the way, this phenomenon is observed in more than 80% of people who used this product.
In general, aromatase inhibitors are quite well-known drugs. Samples of the third generation of blockers "Anastrozol" and, later, "Vorozol" and
"Letrozole," were created as products of the first and second line for treating scattered receptor-positive breast cancer.
Crisin
For weightlifters pharmacological marketoffers also 5,7-dihydroxyflavone ("Krizin"), which athletes are used in very high doses. It has anti-aromatase properties and is produced in two forms - MRM-Chrysin, which contains 500 mg of flawless krizin capsule, and SciFit-Chrysin ES, which contains half the active substance.
The developers do not describe any side effects, butit should be remembered that all substances and drugs that have anti-aromatase action, can cause significant harm to the athlete's body. In addition, they are in the "List of prohibited methods and substances".
Reviews
Many bodybuilders say that, based onexperience of the application of Letrozole ("Femara"), they concluded: this product, solving one task (an increased estrogen index), contributes to the emergence of many other problems. Of course, aromatase inhibitors for men are important. After all, the body (including men) uses estrogens to preserve the health of the immune system, brain work, normal cholesterol, healthy joints, ligaments and so on.
Athletes say that estrogen starts inthe mechanism of muscle growth. Taking 2.5 mg of Letrozole per day, they begin to feel serious injuries of the joint and ligament apparatus and become vulnerable to infectious and viral diseases.
Many athletes are sure that Letrozol canuse only professional bodybuilders in preparation for the competition. Thanks to him, they get rid of excess fluid in the body (professionals do not feel sorry for the victory of health). They are happy to acquire this aromatase inhibitor. The price of them is quite satisfactory.
Some athletes say that Letrozolpositively affects the body even at a dosage of 0.1-0.5 mg. They report that its secondary effect is not worse than other inhibitors and is standard for this type of medication. They assure that subjective sensations, the product quickly reconstructs the volume of testicles, than "Tamoxifen" and "Clomid". They also argue that aromatase inhibitors are drugs whose price justifies the quality.
Some athletes report that any blocker can be used, but considering the high productivity of Letrozol in small doses, it turns out to be the most inexpensive.
"Anastrozole"
Today, "Anastrozole" is the most popular blocker. The cheapest is considered to be Selana. Some aromatase inhibitors in the pharmacy are rare, for example, "Anastrozole Kabi."
Many people do not save on their health and choose quality.
Accept "Anastrozole" in accordance withown level of estradiol. Therefore, the level of estradiol is first tested to adjust the portion based on the analysis. The average classical dosage is 0.5 mg per day.
After ten days again, you need to take tests.If the level of estradiol is standard, you can reduce dosage to 0.5 mg twice a week. If it is still high, the reception must be continued. And this should be done until the level of estradiol is completely restored.
