The drug "Nitrosorbid" - a fairly common remedy. Prescribed medication for cardiac diseases. The active substance is isosorbide dinitrate.
Medicine "Nitrosorbid" instructions for usecharacterizes as a peripheral vasodilator from the group of organic nitrates, oral antianginal agent. The mechanism of action is based on the release of nitric oxide in the smooth muscles of the vessels, a decrease in the activity of protein kinase and other factors that contribute to relaxation in the smooth muscles of the vessels (veins, predominantly). This, in turn, leads to a short-term decrease in blood pressure, relief of pre-and post-loadings on the myocardium, reduction of myocardial oxygen demand. Due to the dilatation (expansion) of the capillaries, the supply of oxygen and the blood supply to the myocardium are improved, and a reflex acceleration of the heart rhythm is also possible.
The medicine "Nitrosorbid" (instruction about ittestifies) in contrast to the drug "Nitroglycerin" is absorbed slowly. On oral administration, the onset of action is observed after thirty to fifty minutes.
Means "Nitrosorbid". Application. Dosage
How is antianginal drug indicated forprevention and elimination of angina attacks, in the rehabilitation treatment for myocardial infarction. The drug is prescribed for heart failure in severe course (as a peripheral vasodilator). In some cases, the drug "Nitrosorbid" instructions for use permits the appointment with endarteritis and other diseases complicated by angiospasm.
The drug is prescribed for adults.Means "Nitrosorbid" instructions for use recommends taking half an hour before meals three times or four times a day for five to ten milligrams. In some cases, single dosages increase to 20-30 mg.
With heart failure in the severe phasemedicine "Nitrosorbid" instructions for use recommends taking 20 ml (two tablets) every four or five hours. In the case of the use of conventional (for oral administration) tablets sublingually (like the drug "Nitroglycerin"), the relief of angina pectoris is likely.
The drug can provoke a number of side effects.effects. These include reflex tachycardia, orthostatic hypotension, skin flushing, drowsiness, nausea, dizziness. In rare cases, angina may increase, collapse, bradycardia. As practice shows, these reactions are eliminated independently after reducing the dosage.
With prolonged use of the drug is likelydevelopment of tolerance to it. In order to prevent such a condition, it is recommended to take breaks of 3-5 days after every three to six weeks of admission. During this period, the drug "Nitrosorbid" can be replaced by another antiangial agent.
Contraindications
The medicine "Nitrosorbid" is not prescribed forstroke (including hemorrhagic), collapse, shock, TBI. The drug is contraindicated in case of hypersensitivity to nitrates, high intracranial pressure, in the acute period of infarction, angle-closure glaucoma with high intraocular pressure, with severe hypotension.
The expediency of taking the medicine "Nitrosorbid" during gestation and lactation is determined by the doctor.
The drug is not prescribed simultaneously with sildenafil (drug "Viagra").
An overdose of the drug "Nitrosorbid" is manifested in the form of dizziness, diarrhea, vomiting, drowsiness, tachycardia, hypotension (severe).
To relieve the condition, the stomach is washed, the patient is transferred to a horizontal position. Symptomatic therapy is indicated.
Before using the drug "Nitrosorbid" should be carefully studied instructions.
