In this article we will consider the instructions for use of "Cardichet", the price and reviews.
It is a drug that is used withthe purpose of stopping and avoiding angina attacks, as well as the treatment of other symptoms of coronary insufficiency on the background of coronary heart disease.
Drug release form and composition
According to the instructions for use, "Cardiket"produced in the form of round white tablets, characterized by prolonged action. They are convex on the one hand, have the inscription SCHWARZ PHARMA, and on the other - with a facet, drawing and engraving, flat. There are ten pieces in one blister, and two or five blisters in a carton box. The composition of one tablet: isosorbide dinitrate (active substance), as well as auxiliary elements: polyvinyl acetate, potato starch, lactose monohydrate, magnesium stearate, talc.
What else does the instruction manual give us to Cardichet? Price and analogues will be presented at the end of the article.
Indications for use
"Cardique" is used in the following cases:
- with long-term treatment of coronary heart disease (as prevention of angina attacks);
- prevention of myocardial infarction (secondary) and treatment of angina (as part of combination therapy);
- long-term therapy of severe chronic heart failure (as part of a combined treatment with cardiac diuretics, glycosides, angiotensin converting enzyme inhibitors).
Contraindications
According to the instructions for use, "Cardique" is not recommended in the following conditions:
- Excessive sensitivity to dinitrate iosorbida, other excipients or nitrates.
- Acute blood circulation defects (collapse, shock).
- Cardiogenic shock (in the absence of measures that support the diastolic final pressure).
- Obstructive hypertrophic cardiomyopathy.
- Cardiac tamponade.
- Constrictive pericarditis.
- Arterial hypotension. Under what pressure does Cardiquet follow the instructions for use? When arterial systolic pressure is less than 90 mm. Hg Art.
- Hypovolemia in severe form.
- Anemia in severe form.
- Severe subaortic, mitral and aortic stenosis.
- Minors are not established as safety and efficacy.
- The simultaneous use of phosphodiesterase-5 inhibitors (including tadalafil, vardenafil, sildenafil).
- Patients with intolerance to galactose from birth or defects in absorption of galactose and glucose, due to the presence of lactose, should not take this drug.
This confirms the instructions for use to"Cardicet". Caution should be taken with: low filling pressure of the left ventricle, including the state of myocardial infarction of acute nature, violation of the activity of the left ventricle (for example, in case of its failure); mitral and / or aortic stenosis of moderate and mild; diseases that are accompanied by excessive pressure inside the skull (an increase in pressure has so far been observed only after the introduction of nitroglycerin in high doses into the vein); cerebral hemorrhage, increased pressure inside the eye, including angle-closure glaucoma, severe liver and / or kidney failure, susceptibility to orthostatic defects of vascular regulation, hypothyroidism, malnutrition and malnutrition; childbearing and lactation period.
This is also described in the instructions for use. The price of "Cardique" interests many.
Dosage and method of administration
Tablets (20 mg) with prolongedaction, assigned one piece twice a day. If the need for medication increases, the dosage can be increased to one pill three times a day.
Таблетки (40 мг) назначаются в начале лечения по one tablet once a day or half a tablet twice a day. If the therapeutic effect is insufficient, the dosage may be increased to one pill twice a day. The second tablet is taken no later than eight hours after the previous one.
Tablets (60 mg) are prescribed at the beginning of treatment byone piece once a day. If necessary, you can increase the dosage to one pill twice a day. No later than eight hours after the previous one, you should drink a second pill.
In the form of capsules, the drug is administered once a day for 120 milligrams.
Лечение нужно начинать с минимальных доз, gradually increase the dosage to the most effective. The decision on the duration of therapy is made by a doctor. The drug is intended for prolonged use, it is impossible without consulting with a specialist to stop taking it.
The drug is used inside, regardless offood intake, not chewed, washed down with liquid. To split a tablet in half, you need to put it on a hard surface upwards with a break line and press with your thumb. She easily divided in half.
Side effects
In accordance with the instructions for use to "Cardique", side effects when taking may be as follows:
- Heart and vascular system:at the beginning of therapy, a headache (so-called “nitrate”) may appear, which most often disappears after a few days if the drug is used later. In some cases, when first taken or when overdosing, there is a reduced pressure, especially in cases where the patient got out of bed, tachycardia is possible (maybe paradoxical bradycardia), dizziness, weakness, lethargy. In rare cases, against the background of a pronounced decrease in pressure, angina pectoris attacks may increase (paradoxical enhancement of angina pectoris attacks). Very rarely are collaptoid states, sometimes with syncope (severe loss of consciousness) and bradycardia.
- Digestive system: in rare cases - dry mouth, vomiting, abdominal pain, nausea, belching.
- CNS: drowsiness, reduced ability to accelerate motor and mental reactions (especially at the beginning of therapy), stiffness, blurred vision, in rare cases - cerebral ischemia.
Allergic reactions: rash on the skin.
Other symptoms: tolerance develops (including cross to other nitrates), hyperemia of the epidermis on the face, exfoliative dermatitis.
This information is available in the application instructions for "Cardiket". Price, reviews and analogues consider below.
Overdose
Signs of overdose:marked decrease in pressure, fainting, dizziness, collapse, headache, feeling of heartbeat, visual disturbances, skin hyperemia, vomiting, methemoglobinemia (anoxia, cyanosis), nausea, hyperpnea, diarrhea, perspiration, dyspnea, coma, bradycardia, dyspnea, diarrhea, perspiration, dyspnea, coma hypertension.
Лечение следующее:the stomach is flushed; if the patient has methemoglobinemia, then a solution of blue methylene 1%, 1-2 milligrams per kilogram of weight is injected into the vein. Symptomatic therapy (with epinephrine and compounds related to it, have low efficiency).
Interaction with other drugs
Hypotensive effect may increase"Kardiket" along with the reception of other vasodilator drugs (vasodilators), beta-blockers, antihypertensives, calcium channel blockers slow, phosphodiesterase 5 inhibitors, which are used for the purpose of therapy of erectile dysfunction, tricyclic antidepressants group, neuroleptics, ethanol, quinidine and novokainamidom.
The simultaneous intake of the drug with dihydroergotamine can cause an increase in the concentration of dihydroergotamine in the blood and thus increase its hypotensive effect.
With the simultaneous use of symptomatic drugs, alpha-blockers may decrease the antianginal effects of "Cardict".
The combination of amiodarone and other drugs, for example, propranolol, nifedipine, verapamil, and Cardict is rational for the treatment of coronary artery disease.
With the simultaneous use of "Kardiketa" and acetylsalicylic acid helps to improve the coronary circulation.
Combined use with atropine (m-holinoblokatorami) increases the likelihood of increased pressure inside the eye.
Adsorbents, enveloping and astringent drugs reduce the absorption of the drug in the gastrointestinal tract.
Application specifics
Instructions for use to "Cardidat" 20 mg reports that during treatment with the drug should monitor heart rate and blood pressure.
With systematic continuous therapy withthe use of high dosages of "Cardicet" can develop tolerance and the emergence of cross-tolerance to other means of the nitrate group. To prevent a decrease in the effectiveness of the drug, one should avoid its constant use in large doses.
Use of "Cardichet" in patients with pulmonaryPrimary diseases may appear temporary hypoxemia due to the redistribution of blood flow of a relative nature in the alveolar hypoventilated zones. In people with IHD, this condition can lead to transient-type myocardial ischemia.
In acute myocardial infarction or heart failure, the drug should be used only in the case of scrupulous clinical observation of the patient.
To prevent an increase in angina attacks, you should avoid sudden cancellation.
In case of treatment with "Cardicom", if a stenocardial attack occurs, in order to relieve it, you need to use additional fast-acting nitrates.
In order to avoid undesirable decrease in pressure it is necessary to adjust the dosage individually.
According to the instructions for use and reviews to“Cardicet”, during treatment, pressure may decrease; dizziness appears if you move dramatically from a lying or sitting position to a vertical position, as well as when using ethanol, hot weather, and performing exercises. There may also be increased angina with a sudden decrease in pressure, ischemia, which can lead to myocardial infarction or sudden death.
The severity of headaches during therapy with this drug may be reduced by reducing the dosage and / or the simultaneous use of agents containing menthol ("Validol").
With frequent use without intervals, free from the reception, may appear addictive, which requires an increase in dose.
To prevent the emergence of tolerance,It is advisable to observe a daily “nitrate-free interval” (preferably at night) for 8–12 hours. In the majority of patients, such treatment becomes more effective than continuous.
If you maintain or have a strong expression of dry mouth or blurred vision, discontinue treatment.
During therapy, alcohol should be excluded.drinks. In addition, you should avoid driving a vehicle and practicing such activities that are dangerous and require high concentration of attention, as well as accelerated psychomotor reactions.
With caution, the drug is prescribed for severe kidney and liver failure, since there is a likelihood of methemoglobinemia.
We have reviewed the instructions for use. Analogs of "Cardique" are given below.
Drug analogues
"Cardique" has the following structural analogs forits active component: TD-spray Iso Mac, Isocket, Aerosonit, Nitrosorbid, Dinisorb, Cardix, Isacardine, Isosorbide Dinitrate, Izo Mac Retard, Izolong , "From Mac Spray." They must select a doctor.
Price
The cost of the drug from 120 - 200 rubles per pack. It depends on the region and the pharmacy network.
Reviews
Patients respond more favorably to the "Cardiquete". The drug quickly adjusts the functioning of the heart muscle. There is a high efficiency means.
The most common adverse symptoms observed in patients are headaches of varying degrees of intensity.
The article presented instructions for use, price, and reviews of the drug “Cardiquet”.
