Myasthenia gravis - quite commondisease. It manifests as asthenic bulbar paralysis. It is characterized by pronounced weakness and rapid fatigue of the muscles. During the disease, any part of the body can be affected, but the lips, tongue, pharynx and neck are more vulnerable. Such pathology requires professional treatment. One of the claimed and high-quality drugs for the treatment of myasthenia gravis is the medicine "Kalimin". Instructions for use are in the package with tablets.
Structure of the medicine
The agent "Kalimin" is considered an inhibitorcholinesterase. Tablets are white, slightly convex. They have an oblong shape with small roughnesses. In the middle of the tablet is divided by a strip. The main substance in the composition is pyridostigmine bromide in a dosage of 60 mg. Auxiliary components of the drug are microcrystalline cellulose, corn starch, silicon dioxide, polyvidone, glutamic acid hydrochloride, purified water, magnesium stearate.
The drug is produced in dark vials, 100tablets in each. Despite the fact that the pill "Kalimin" is dispensed without a prescription, the instructions for use must be studied before starting therapy.
The action of the tablets "Kalimin"
The drug improves nerve and muscle transmission,increases the motility of the gastrointestinal tract, increases the tone of the bladder, bronchi, the secretion of the endocrine glands. Causes a bradycardia, a weak miosis, a spasm of accommodation. Achievements of the greatest effect in the body should be expected in 2 hours. Bioavailability of the drug is 20%.
Taking medication with food does not lowerbioavailability, but lengthens the time to achieve the effect by 1.5 hours. The agent does not penetrate the blood-brain barrier. The drug basically does not combine with plasma. In a certain amount, it is metabolized in the liver, forms non-active metabolites after cleavage. The medicine "Kalimin" is excreted by the kidneys in the unaltered form. Testimonials, indications, correct dosage - with all this you should read before the treatment.
Indications and contraindications
Indication for the use of the drug is consideredmyasthenia gravis. You can not prescribe the drug for bronchial asthma and chronic obstructive bronchitis. Obstructive disease of the biliary and urinary tract is also a contraindication. Do not drink tablets during mechanical intestinal obstruction, myotonia. Contraindications to the use of the drug are pregnancy and lactation, the age of 18 years. With increased sensitivity to the components of tablets, they are not recommended.
Before the beginning of treatment it is worth to carefully read the contraindications to the use of the "Kalimin". Instructions for use, feedback - all this is important information for patients.
Dosage of the drug
The tablet is taken orally.It is recommended to drink with a lot of liquid. To achieve a quick effect, it is worth using an agent on an empty stomach. At the beginning of the disease you need to drink half or whole pill once or twice a day. In more severe cases of myasthenia gravis, it is prescribed to take one to three tablets two or four times a day. The maximum allowable dose for taking a day is 12 tablets. The daily rate and duration of treatment are determined by the doctor on an individual basis. The peculiarities of the organism and the progression of the disease are taken into account.
Patients suffering from kidney disease, it is worthtake medication in a reduced dosage. It should be borne in mind that may lead to the development of side effects means "Kalimin". Instructions for use contains information about the accompanying treatment of negative reactions.
Overdose
With an overdose of the drug increasessalivary, sweat, tear glands. The patient becomes red, weakness appears, vision is disturbed. Involuntary urination and defecation may occur. The patient complains of nausea, vomiting, pressure decreases, increases bronchospasm. In severe cases of overdose, cardiac arrest may occur, leading to death. This condition requires immediate assistance. The antipode for the tablets "Kalimin" is considered "Atropine". It must be administered intravenously at a dose of 2 ml.
Further, depending on the condition of the patient,repeat administration of the drug after three hours. It is recommended to conduct a gastric lavage and give an adsorbent to drink. The patient should be supervised by medical personnel so that breathing does not stop. According to the testimony you need to hold resuscitation. Such severe consequences of overdose can have the drug "Kalimin". Reviews show that bad effects can only be expected if the medication is used incorrectly.
Interaction with other groups of drugs
"Atropine" reduces the effect of the drug "Kalimin",but does not affect the skeletal muscles. Pyridostigmine bromide, which is part of the tablets, enhances the action of Morphine and barbiturates. Completely incompatible drug with ethanol. Reduce the pronounced effect of the drug "Quinidine", ganglioblockers, antidepressants, anti-epileptic and anti-Parkinsonian drugs.
Reviews about the drug
Patients who suffer from myastheniaspeak positively about the drug "Kalimin". Instructions for use will acquaint the patient with contraindications and indications in an accessible form. Tablets in a short time give a positive therapeutic effect, patients note. The drug has an affordable price and good quality.
The tool is not addictive and often tolerated quite well. However, there are cases of severe adverse events.
