/ Gentamicin ointment: mechanism of action and application

Gentamicin ointment: mechanism of action and application

As a result of the vital activity of microorganisms(Micromospora purpurea) forms an antibiotic - gentamicin. It is used in the form of gentamicin sulfate (Gentamicyni sulfas). This powder is readily soluble in H2O. Aqueous solutions are fairly persistent, can withstand boiling. Form release - 4% aqueous solutions, powder and 0.1% ointment. When preparing the ointment use additional substances (petrolatum white and paraffin). Gentamicin ointment is used for external use. The drug contains an antibiotic (Gentamicyni sulfas), belonging to the aminoglycoside series. It shows a wide spectrum of action.

Gentamicin ointment: mechanism of action

According to the spectrum of antibacterial action,differs from other antibiotics of this group. It shows bactericidal effect on the majority of gram-negative and gram-positive microorganisms, including Proteus, Pseudomonas aeruginosa, klepsiels, Campylobacteria, Escherichia coli, Staphylococcus and others. It is less effective against stethococci, enterococci, clostridia. With the combined administration of gentamycin with penicillins (oxacillin, carbenicillin, ampicillin), a good bactericidal effect is obtained with regard to entero- and streptococci. Gentamycin sulfate does not affect anaerobic bacteria, viruses, protozoa and fungi. Resistance of microorganisms to the action of antibiotic is developed gradually. It should be noted that strains resistant to the action of antibiotics such as kanamycin and neomycin, show resistance to the action of gentamicin (cross resistance).

Поскольку мазь гентамициновая содержит антибиотик aminoglycoside series, it poorly penetrates through the skin and mucous membranes. In this regard, this ointment does not show any resorptive action. The duration of the action after a single application can last up to 8-12 hours. Therefore, gentamicin ointment is applied to the damaged surface once or twice a day, taking into account the severity of the lesion and the nature of the course of the underlying pathology. The active substance (antibiotic) is excreted from the body by the kidneys, practically unchanged, in sufficiently high concentrations.

Gentamicin ointment: instructions for use

This drug is widely used in surgicalpractice for the treatment of wounds in the second phase of the wound process in order to prevent the development of purulent infection. Gentamicin ointment is used for burns and frostbite. Dermatologists use ointment for treating skin diseases of infectious etiology (superficial folliculitis, pyoderma, dermatitis, eczema, furunculosis, ulcers, acne, etc.) caused by bacteria susceptible to gentamicin. Gentamicin ointment can also be used in the treatment of domestic injuries (small wounds, scratches).

Method of application

Following the appropriate (adhering to the rulesasepsis and antiseptics) treatment of wounds and burns Gentamicin ointment directly impose on the wound surface, then impose a gauze bandage. An antibiotic ointment can also be applied first to a bandage, and then to the surface of the wound. As a rule, ointment is used twice a day for treating wounds, and twice a week for treating burns. Depending on the form and severity of the disease, treatment can last up to two weeks. In the presence of ulcers and erosion, the wound is first treated with disinfectants (3% hydrogen peroxide, 2% alcoholic solution of boric acid), after which gentamicin ointment is used. The use of the drug may cause side effects, which manifest themselves in the form of allergic reactions and hyperemia. The use of gentamicin ointment is contraindicated in the presence of allergic reactions to the antibiotic and in the first phase of the wound process.