In the form of an infusion solution, tablets fororal use, liquid for the treatment of organs of vision on the sale of the drug "Tsiprolet". The use of the drug is possible strictly under the control of the doctor - the substance belongs to the antimicrobial class, it has a rather strong effect, therefore it requires compliance with safety rules. It is important to follow the manufacturer’s recommendations listed in the instructions. Consider it in more detail.
general information
The instructions to the antibiotic "Tsiprolet" states:The main active ingredient that ensures the effectiveness of the application is ciprofloxacin. It comes in different versions, so it can be used as a therapeutic agent for a wide range of diseases. The mechanics of the effect on the human body are approximately the same for all variants of the drug, the distinctive features are associated with the rules of dosage, use, application of the substance.
Quite often, doctors recommend staying atinfusion solution. In the instructions for use of the antibiotic "Tsiprolet" in this form of release, the manufacturer indicates that in one vial contains 100 ml of the drug, of which 200 mg is the active substance. Also used additional compounds that simplify the use of the drug and ensure its long shelf life. These are lactic and hydrochloric, citric acids, sodium compounds, special purified water.
What else do you have?
Presented in the sale of eye drops "Tsiprolet".Instructions to them clarifies that the drug is also based on ciprofloxacin, is available in the form of a colorless liquid or substance with a slight yellowish tinge. Drops should be clear, without sediment. In addition to the active component, per 1 ml added in the amount of 3 g, there are additional substances in the composition of the medication. These are various acids, sodium compounds, purified water. The substance is packaged in five-milliliter vials with dispensers placed in cardboard boxes. In addition to the medication itself, the instructions for Tsiprolet drops are always present.
Finally, the antibiotic comes in pill form.form. This option is intended for oral use. There are three options for release: 250 mg of active compound and twice as much, as well as a combined preparation containing 500 mg of ciprofloxacin and 600 mg of tinidazole. Tablets are packed with blisters in cardboard boxes. In one blister - a dozen capsules, in one box - one blister. The manufacturer completes all forms of release instructions for use. “Tsiprolet” 250 mg, 500 mg, 500 + 600 mg has proven to be a reliable drug, but before primary use it is necessary to carefully read the accompanying documentation, get acquainted not only with the list of indications, but also contraindications, as well as possible negative consequences of use.
Is there an alternative?
There are quite a few on sale"Tsiprolet". Instructions for this drug mentions that the main active ingredient is ciprofloxacin. He is also present in the medicines "Ciprofloxacin", "Tsifran". The number of possible substitutes for the money in question also includes Basigen, Betaciprol, and Affitro. The choice of drug for replacement must be coordinated with the doctor, taking into account which format of use is preferred for a particular patient. For example, if an antibiotic is needed for oral use, possible alternatives to the “Tsiprolet” under review are “Quintor”, “Protsipro”, “Tseprova”.
If it is impossible to purchase the writtenDoctor means you need to contact the doctor and explain the reasons why you can not buy "Tsiprolet." Instructions for the use of analogues contain sufficiently detailed information on the technical features of the preparations, but it is almost impossible to select the optimal replacement without having a specific education. Sometimes the doctor recommends to stop on the ointment "Oftocipro" or drops of "Rotsip", in other cases the best solution would be "Nircps" or "Tsiprinol".
To some extent, replacing the described meansconsider drops for instillation into the ears “Tsipromed”, for the eyes - “Ciprolon”, tablets “Ciprobid” and “Ecocifol”. The “Tsipropan” and “Cifloxinal” tablet editions have a good reputation. For injective administration, the doctor may offer alternatives to the drug in question, for sale presented under the names “Tsiprobay”, “Tsiproksil”, “Tsiprofloksabol”, “Tsifratsid”, “Tsiprolaker”.
Tsiprolet: technical issues
As follows from the instructions for Tsiprolet (250 mg andother dosages, all forms of release), the drug belongs to the class of antimicrobial fluoroquinolones. It has a wide range of efficiency. The active ingredient is a product of fluoroquinolone transformation. Under its influence, the DNA giraz of the pathological bacterium is inhibited, the synthesis of the molecule is lost, the development and reproduction of the causative agent is disturbed. "Tsiprolet" provokes morphological cellular changes, which soon leads to the death of the pathogen.
In the instructions to "Tsiprolet" (eye drops,tablets and injection), the manufacturer indicates that the substance has a bactericidal effect on gram-negative life forms. “Tsiprolet” is effective both against those who are at rest and against those that are currently at the stage of division. The breadth of the spectrum of action is explained by the fact that not only is the effect on the DNA gyrase, but also cell lysis is observed. If an infection has occurred by gram-positive microscopic life forms, the active substance of Tsiprolet will affect them only at the time of cell division.
Nuances of use
In the instructions for the tablets "Tsiprolet" dropsfor injection, it is indicated that for a macroorganism a substance is toxic to a small extent. This is due to the fact that DNA gyrase is inherent only in pathological forms of life. Studies have shown that penetration into the body of the active ingredient does not lead to the formation of resistance to other antimicrobial substances operating under a different scenario. Experiments have proven that "Tsiprolet" is effective in infecting life forms that are immune to the penicillin, tetracycline, cephalosporins and aminoglycosides. The effectiveness of antibiotic treatment and other diseases, the causative agents of which were resistant to a wide range of drugs available to humans, was observed.
В инструкции к «Ципролету» (таблеткам, раствору, drops) the manufacturer indicates that the effectiveness of the use of the drug during infection with gram-negative life forms, including a wide range of enterobacteria, moraxells and pseudomonads, has been proven. “Tsiprolet” can be used against Neisseria. Allowed to use when infected with intracellular life forms: Legionella, Listeria, Corynebacterium. Proved the effectiveness of treatment when infected with Staphylococcus, Streptococcus.
Effective and not too
In the manual "Tsiprolet" (500 mg, 250 mg,solution, drops) it is mentioned that the drug is ineffective against staphylococci, which is resistant to methicillin. Resistance to the substance is different and treponema, ureaplasma, clostridia and some other forms of life. To ensure the effectiveness of the use of “Tsiprolet” in a particular case, it is advisable to first make an analysis in order to identify the features of the microscopic flora.
As studies have shown (and this is recorded ininstructions for "Tsiprolet" 500 mg and other forms of release), pathological forms of life can develop resistance to ciprofloxacin, but the process is very slow. This is due to the fact that after applying the substance there is practically no persistent cells. In addition, bacterial cells cannot produce such enzymes that would inhibit the activity of ciprofloxacin.
What happens in the body?
According to the instructions to "Tsiprolet" forinjective administration, soon after penetration into the vein 200-400 mg of the active ingredient, the maximum concentration in the blood is reached. Indicators - 2.1 µg / ml for a lower dose, for twice as much - 4.6 µg / ml. To achieve these indicators, on average, one hour is required. The active ingredient at 20-40% enters into strong bonds with plasma proteins. The volume of distribution is estimated at 3 l / kg, some - a little less, in some patients - a little more.
The instructions for the tablets "Tsiprolet" 500 mg andother dosages, injection solution manufacturer pays attention to the ability of ciprofloxacin to distribute well in organic tissues. The exception is fatty structures, so "Tsiprolet" does not affect the nerve tissue. On average, in the tissues, the accumulation of the active component exceeds the inherent blood serum by 2-12 times. Sufficient concentrations for the presence of a pronounced therapeutic effect are observed in body fluids (secretion of salivary, seminal glands, bile). "Tsiprolet" affects the organs of the reproductive, endocrine, respiratory system, kidney and the system for removing urine from the body, bones, muscle structures. There is an accumulation of ciprofloxacin in the synovial fluid, in the cartilage elements of the joints, in the skin.
Important Features
Relatively low abilitiesCiprofloxacin has (as follows from the instructions to the Ciprolet tablets, 500 mg and other antibiotic release options) for spinal cord fluid. If there are no foci of inflammation in the tissues of the brain membranes, the concentration is on average up to 10% relative to that of blood serum. In the presence of foci of inflammation, a rise in the content of up to 37% is possible.
It has been revealed that ciprofloxacin can penetrate intoeye fluid, bronchial secretions, into the lymphatic system. The substance can pass through the placenta, which explains certain restrictions on the use of the drug, prescribed in the instructions to "Tsiprolet". In blood neutrophils, concentration values are higher than in plasma, 2-7 times.
Reaction features
In the manual of “Tsiprolet” the manufacturer indicatesthat the transformation of the active component takes place predominantly in the liver, about a third of the total dose received into the body is converted. Reaction products have weak pharmacological activity. Currently, information on four reaction products that can show any pronounced effect on the patient's condition is taken into account.
Half-life, according to the instructions“Tsiprolet”, is estimated at an average of 5.5 hours. If the patient suffers from a deficiency in the functioning of the kidneys in a chronic form, the interval can be lengthened to 12 hours. Elimination is largely carried out by filtration, secretion through the tubules. Up to 70% of the active component is eliminated from the body unchanged, one tenth - with urine in the form of reaction products. Other volumes leave the patient through the intestinal tract.
A small percentage of ciprofloxacin is found in breast milk.
After the introduction of the drug in a vein in urinethe concentration of the first couple of hours is greater than in blood serum, about a hundred times. These values are many times greater than the minimum dose, which could inhibit the vital activity of pathogenic agents that infect the urinary tract.
Nuances of use
Kidney clearance is estimated at 3-5 ml / kg incalculated for a minute. General - about 8-10 ml / kg per minute. If the creatinine clearance is more than 20 ml / min, the percentage of medication eliminated by the kidneys decreases. In this case, there is no accumulative effect; ciprofloxacin is not stored in the tissues In chronic renal failure, the metabolism of the active substance is enhanced, a larger percentage is excreted through the intestinal tract, which compensates for the imperfection of the renal system.
When will help?
Adult "Tsiprolet" is shown during infectionbacteria, for which tests confirm sensitivity to the active substance. Can be used for diseases of the respiratory system, upper respiratory tract, kidney infection, ways of removing urine. If prostatitis due to bacteria is detected in a chronic form, “Tsiprolet” is used after confirming the effectiveness of the agent in a particular case. You can use the drug for gonorrhea, if the disease is not accompanied by complications, with typhoid, Shigella infection, infection of soft tissues, skin, bone and joint structures. "Tsiprolet" is indicated in septicemia, infection, which developed when immune status is inhibited. As a prophylactic agent, “Tsiprolet” is used if an operation is planned or if the risk of anthrax infection is high. You can use the drug for the treatment of this disease, localized in the lungs. In combination with metronidazole, the drug is indicated for intra-abdominal infection.
According to the instructions for children "Tsiprolet" you canuse if cystic fibrosis is detected, against which background complications have developed, and tests for microflora have shown Pseudomonas aeruginosa. The drug is approved for patients from the age group of 5-17 years. Also in childhood, the drug can be used as a means of preventing and eliminating anthrax, localized in the respiratory system. The drug is effective if the person is infected with Bacillus anthracis.
Absolutely not!
It is not allowed to use "Tsiprolet" ifan increased susceptibility to the active component of the drug or any other substances used by the manufacturer in the manufacture of one form or another. You can not use the drug for increased susceptibility of other drugs from the class of fluoroquinolones.
"Tsiprolet" is prohibited for pregnant women andnursing mothers, because the remedy penetrates the placental barrier, is excreted in breast milk. Until adulthood, the drug can be used only if there are to that strict indications mentioned above. Use of the substance by children can lead to undesirable effects, since the skeleton has not yet formed. An exceptional situation - cystic fibrosis, which led to bacterial complications, as well as the possibility of becoming ill with anthrax. Even with such diagnoses and dangers, “Tsiprolet” is not used in the treatment of children under five years of age.
You can not use "Tsiprolet" and drugs containing tizanidine. Such a combination can cause a strong decrease in pressure in the arteries. The patient irresistibly pulls to sleep.
It is possible, but very carefully
It is allowed to use "Tsiprolet" if there isthe ability to monitor the patient's condition when there are problems with blood flow in the brain, mental disorders, cerebral arteriosclerosis, epilepsy. If possible, to keep the patient's condition under control can be prescribed for the treatment of “Tsiprolet” in case of insufficiency of the liver and kidneys in a pronounced form. Carefully use the tool in the treatment of the elderly, as well as people suffering from heart disease or electrolyte imbalance in the body.
Caution from the doctor and patient requiresa combination of "Tsiprolet" and a number of drugs. These are primarily drugs that can change the duration of the QT interval. Gently combine "Tsiprolet" and agents that affect chemical reactions using CYP 450 1A2 enzyme. If in the past a person suffered a violation of the functionality of the tendons against the use of quinolones, ciprofloxacin is allowed only with the possibility of permanent monitoring of important indicators of the body.
How to use the solution?
Одна из самых эффективных форм выпуска "Tsiprolet" is a fluid for injection into a vein. The drug is poured within half an hour if the indicated dosage is 200 mg. If the doctor recommended to use twice the large volumes, the procedure is extended to one hour. Solutions prepared for use can be combined with products of Ringer-lactate, Ringer, sodium chloride, dextrose, fructose. It is allowed to use a mixed preparation in which “Tsiprolet” for injections is combined with sodium chloride and dextrose at the same time.
Features of the course, frequency and dosage determinesthe doctor, based on the age, condition of the patient, diagnosis, severity of the disease. In particular, when infected with the ENT organs, Tsiprolet is shown twice a day with a ten-day program, a dose of 200-400 mg. When the respiratory system is infected, similar dosages are also consumed twice a day, but the duration of treatment varies from a week to two. If severe pneumonia is detected, cystic fibrosis with complications, it is necessary to inject 400 mg of ciprofloxacin three times every day. The course stretches for a week or two.
Application options: what is?
Можно использовать «Ципролет», если инфекционный the agent has infected the urinary system. For acute infection without complications, the patient is shown twice a day to use 100 mg of the active substance. The duration of the program is from a week to two. For women at reproductive age with cystitis, “Tsiprolet” is shown once in an amount of 100 mg. If the disease occurs with complications, a single dosage is doubled, the drug is used twice a day for no more than two weeks in a row.
If prostatitis is detected, it is provoked.pathological bacteria, if the disease occurs in a chronic form, “Tsiprolet” in the form of a solution is recommended to be used twice daily for four weeks in a row. Single dose - 400 mg of ciprofloxacin.
For gonorrhea without complications, the drug is once consumed in an amount of 100 mg. If the form is extragenital, this dose should be used twice a day.
Typhoid fever requires ciprofloxacin in the amount of400 mg twice daily for ten consecutive days. Twice as little dose is enough for diarrhea caused by infection. The drug is also consumed twice daily, and the duration of the program - up to a week. For especially severe infectious processes, ciprofloxacin can be applied in the amount of 400 mg three times daily. If infection of soft tissues, skin is detected, the disease is mild or moderate in severity, it is recommended to use ciprofloxacin twice daily in an amount of 400 mg. If the infection is severe, the frequency is increased to three times each day. The duration of the program is from a week to two.
Do I need this?
In reviews about “Tsiprolet”, the persons taking the drugnote that the antibiotic is extremely effective. He also has weaknesses: a predominant percentage of those undergoing treatment acknowledge that therapy was accompanied by side effects. At the same time, many mention that “Tsiprolet” was prescribed for serious diseases, when the side effects are quite low cost of recovery.
It is noted that "Tsiprolet" helps only when applying the course. Independent use can cause deterioration of the patient.
